Results 91 to 100 of about 301,037 (257)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Impact evaluation ofwelfare actions over a community in Colombia, using a data correlated model

Revista Facultad Nacional de Salud Pública, 2010
The impact evaluation of a communitarian program sometimes is based on statistical techniques such as linear regression models analysis when the goal is usually to quantify its effects on both social and welfare characteristics of a community.
Juan C. Salazar U, Marisol Valencia C
doaj  

Comparing regression estimation techniques when predicting diameter distributions of Scots pine on drained peatlands

Silva Fennica, 2007
We compared different statistical methods for fitting linear regression models to a longitudinal data of breast height diameter (dbh) distributions of Scots pine dominated stands on drained peatlands.
Siipilehto, Jouni, Sarkkola, Sakari, Mehtätalo, Lauri   +2 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Genome-Wide Association Study for Nodule Traits in Guar

Current Issues in Molecular Biology
Guar [Cyamopsis tetragonoloba (L.) Taub] is a diploid legume crop cultivated for galactomannan (guar gum) extracted from the endosperm of the seed. Previous studies have suggested that nodulation of guar can be poor in field conditions; however, solid ...
Shubham Malani, Waltram Ravelombola, Aurora Manley, Hanh Pham, Madeline Brown, Md. Mezanur Rahman   +5 more
doaj   +1 more source

On Mallows' Cp in the multivariate linear regression model under the uniform mixed linear constraints

Journal of the Japan Statistical Society, Japanese Issue, 1986
We expand the Mallows' Cp into the multivariate linear regression model along the framework of \textit{E. R. Berndt} and \textit{N. E. Savin} [Econometrica 45, 1263-1277 (1977; Zbl 0368.62030)]. Also, by using the Cp, we derive the optimal critical value for the Wald test in the multivariate linear regression model under the uniform mixed linear ...
openaire   +2 more sources

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Comparing Year-Class Strength Indices from Longitudinal Analysis of Catch-at-Age Data with Those from Catch-Curve Regression: Application to Lake Huron Lake Trout

Fishes
Fish year-class strength (YCS) has been estimated via longitudinal analysis of catch-at-age data and via catch-curve regression, but no study has compared the two approaches.
Ji X. He, Charles P. Madenjian
doaj   +1 more source