Results 91 to 100 of about 1,409,985 (359)
The association between urinary phthalate metabolites and serum thyroid function in US adolescents
Scientific Reports, 2023 The aim was to investigate the association between mixed exposure to phthalates and serum thyroid function among US adolescents. The study used 2007–2008 survey data from the National Health and Nutrition Examination Survey (NHANES).
Shi-ting Xiang +5 more
doaj +1 more source
Bayesian Inference for Generalized Additive Regression based on Dynamic Models [PDF]
, 1998 We present a general approach for Bayesian inference via Markov chain Monte Carlo (MCMC) simulation in generalized additive, semiparametric and mixed models.
Fahrmeir, Ludwig, Lang, S.
core +2 more sources
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
IFAC Proceedings Volumes, 2009 We present a method for detecting changes and estimating parameters in AR(X) models. The method is based on the assumption of piecewise constant parameters resulting in a sparse structure of their ...
Salehpour, Soheil +2 more
openaire +3 more sources
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Penalized additive regression for space-time data: a Bayesian perspective [PDF]
, 2003 We propose extensions of penalized spline generalized additive models for analysing space-time regression data and study them from a Bayesian perspective.
Fahrmeir, Ludwig +2 more
core +3 more sources
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Methods in Ecology and EvolutionBiological data often violate the assumption of constant variance, yet such heteroscedasticity can reflect meaningful biological processes such as plasticity, canalization or stress responses. Despite this, most models treat variance as statistical noise.
Shinichi Nakagawa +6 more
doaj +1 more source
A review of R-packages for random-intercept probit regression in small clusters [PDF]
, 2016 Generalized Linear Mixed Models (GLMMs) are widely used to model clustered categorical outcomes. To tackle the intractable integration over the random effects distributions, several approximation approaches have been developed for likelihood-based ...
Josephy, Haeike +2 more
core +3 more sources