Results 61 to 70 of about 1,394,927 (329)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Novel metrics for growth model selection

Emerging Themes in Epidemiology, 2018
Background Literature surrounding the statistical modeling of childhood growth data involves a diverse set of potential models from which investigators can choose.
Matthew R. Grigsby, Junrui Di, Andrew Leroux, Vadim Zipunnikov, Luo Xiao, Ciprian Crainiceanu, William Checkley   +6 more
doaj   +1 more source

Nonlinear quantile mixed models

, 2019
In regression applications, the presence of nonlinearity and correlation among observations offer computational challenges not only in traditional settings such as least squares regression, but also (and especially) when the objective function is non ...
Geraci, Marco
core   +1 more source

Bayesian separation of spectral sources under non-negativity and full additivity constraints [PDF]

, 2009
This paper addresses the problem of separating spectral sources which are linearly mixed with unknown proportions. The main difficulty of the problem is to ensure the full additivity (sum-to-one) of the mixing coefficients and non-negativity of sources ...
Bishop, Cardoso, Carteret, Chang, Cichocki, Comon, Comon, Cédric Carteret, Dandeu, de Juan, Djurić, Dobigeon, Dobigeon, Dobigeon, Févotte, Gelman, Gelman, Godsill, Hoyer, Hsiao, Hyvärinen, Jean-Yves Tourneret, Kitamura, Lee, Malinowski, Mazet, Miskin, Moussaoui, Moussaoui, Nicolas Dobigeon, Plumbley, Plumbley, Punskaya, Robert, Robert, Robert, Robert, Sajda, Saïd Moussaoui, Snoussi, Tugnait   +40 more
core   +5 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Varying coefficient models as Mixed Models : reparametrization methods and bayesian estimation [PDF]

, 2013
Non-linear relationships are accommodated in a regression model using smoothing functions. Interaction may occurs between continuous variable, in this case interaction between nonlinear and linear covariate leads to varying coefficent model (VCM), a ...
Freni Sterrantino, Anna
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Dynamic Misspecification in Nonparametric Cointegrating Regression [PDF]

Linear cointegration is known to have the important property of invariance under temporal translation. The same property is shown not to apply for nonlinear cointegration.
Ioannis Kasparis, Peter C.B. Phillips
core   +3 more sources

Factors associated with parasite dominance in fishes from Brazil

Revista Brasileira de Parasitologia Veterinária, 2016
The present study used regression models to evaluate the existence of factors that may influence the numerical parasite dominance with an epidemiological approximation. A database including 3,746 fish specimens and their respective parasites were used to
Cristina Fernandes do Amarante, Wagner de Souza Tassinari, Jose Luis Luque, Maria Julia Salim Pereira   +3 more
doaj   +1 more source