Results 111 to 120 of about 2,678,398 (281)

Multivariate linear regression model based on cross-entropy for estimating disorganisation in drone formations. [PDF]

Sci Rep, 2023
Gackowska M, Cofta P, Śrutek M, Marciniak B.   +3 more
europepmc   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Intrinsic Functional Partially Linear Poisson Regression Model for Count Data

Axioms
Poisson regression is a statistical method specifically designed for analyzing count data. Considering the case where the functional and vector-valued covariates exhibit a linear relationship with the log-transformed Poisson mean, while the covariates in
Jiaqi Xu, Yu Lu, Yuanshen Su, Tao Liu, Yunfei Qi, Wu Xie   +5 more
doaj   +1 more source

Multivariate piecewise linear regression model to predict radiosensitivity using the association with the genome-wide copy number variation. [PDF]

Front Oncol, 2023
Tobiasz J, Al-Harbi N, Bin Judia S, Majid Wakil S, Polanska J, Alsbeih G.   +5 more
europepmc   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Smoothing Estimation of Parameters in Censored Quantile Linear Regression Model

Mathematics
In this paper, we propose a smoothing estimation method for censored quantile regression models. The method associates the convolutional smoothing estimation with the loss function, which is quadratically derivable and globally convex by using a non ...
Mingquan Wang, Xiaohua Ma, Xinrui Wang, Jun Wang, Xiuqing Zhou, Qibing Gao   +5 more
doaj   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

A Piecewise Linear Regression Model Ensemble for Large-Scale Curve Fitting

Algorithms
The Linear Hinges Model (LHM) is an efficient approach to flexible and robust one-dimensional curve fitting under stringent high-noise conditions. However, it was initially designed to run in a single-core processor, accessing the whole input dataset ...
Santiago Moreno-Carbonell, Eugenio F. Sánchez-Úbeda   +1 more
doaj   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source