Results 91 to 100 of about 427,856 (306)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Automatic Construction of Hypotheses for Linear Objects in Digital and Laser Scanning Images [PDF]
Revista Brasileira de Cartografia, 2004 This paper presents an automatic road hypotheses approach using digital image and laser scanning image combining various Digital Image Processing techniques. The semantic objects, in this work, are linear features, such as, roads and streets.
Quintino Dalmolin +2 more
doaj
Archives of Plastic Surgery, 2016 Background Accurate breast volume assessment is a prerequisite to preoperative planning, as well as intraoperative decision making in breast reconstruction surgery.
Woo Yeon Lee +4 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Computer models for the design and optimization of a linear slot scanning mammography system
, 2008 Includes abstract. Includes bibliographical references (p. 143-151)
Hussein, Khalid Ibrahim
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Evidence for Nodal Superconductivity in LaFePO from Scanning SQUID Susceptometry [PDF]
, 2009 We measure changes in the penetration depth {lambda} of the T{sub c} {approx} 6 K superconductor LaFePO. In the process scanning SQUID susceptometry is demonstrated as a technique for accurately measuring local temperature-dependent changes in {lambda ...
Erickson, Ann S. +9 more
core
Tree Species Recognition Based on Airborne Laser Scanning and Complementary Data Sources
, 2014 Species-specific information is important for many tasks related to forest management. We review the use of airborne laser scanning (ALS) and complementary data for providing this information.
Sveriges lantbruksuniversitet. +1 more
core +1 more source
Hysteresis and scanning curves in linear arrays of mesopores with two cavities and three necks. classification of the scanning curves [PDF]
, 2015 Adsorption of argon at 87K in a linear array of slit mesopores composed of two cavities and three necks has been investigated using Grand Canonical Monte Carlo simulation.
Tan, Shiliang Johnathan +3 more
core +1 more source