Results 101 to 110 of about 427,856 (306)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Dominant Upper Extremity Kinematics and Muscular Activity in Sonographers during Kidney Scanning

, 2012
Due to the prevalence of work-related musculoskeletal disorders in sonographers, this study evaluated upper extremity kinematics and determined if co-contraction was present during kidney scans. The results provided a greater understanding of joint range
Edwards, Jennifer Elizabeth
core  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Design optimization of permanent magnet actuators. [PDF]

, 1992
This study describes the design optimization of permanent actuators, of both rotary and linear topologies. Parameter scanning, constrained single and multi-criterion optimization techniques are developed, with due emphasis on the efficient ...
Widdowson, G P
core  

Dirac surface states and nature of superconductivity in noncentrosymmetric BiPd

, 2015
In non-magnetic bulk materials, inversion symmetry protects the spin degeneracy. If the bulk crystal structure lacks a centre of inversion, however, spin-orbit interactions lift the spin degeneracy, leading to a Rashba metal whose Fermi surfaces exhibit ...
Yaresko, Alexander, Peets, Darren C., Sun, Zhixiang, Maldonado, Ana Isabel, Wahl, Peter, Enayat, Mostafa, Lithgow, Calum, Yelland, Ed, Schnyder, Andreas P.   +8 more
core   +1 more source

Efficient linear phase contrast in scanning transmission electron microscopy with matched illumination and detector interferometry

Nature Communications, 2016
Scanning transmission electron microscopy is a powerful material probe, but constrained to large atomic number samples due to the issues of beam damage and weak scattering.
Colin Ophus, Jim Ciston, Jordan Pierce, Tyler R. Harvey, Jordan Chess, Benjamin J. McMorran, Cory Czarnik, Harald H. Rose, Peter Ercius   +8 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Diagnostic Accuracy of Full-Body Linear X-Ray Scanning in Multiple Trauma Patients in Comparison to Computed Tomography

, 2016
Purpose: The purpose of this study was to evaluate the diagnostic accuracy of full-body linear X-ray scanning (LS) in multiple trauma patients in comparison to 128-multislice computed tomography (MSCT). Materials and Methods: 106 multiple trauma patients
Jöres, Andreas, Bonel, Harald Marcel, Exadaktylos, Aristomenis, Klink, T, Heverhagen, Johannes   +4 more
core   +1 more source

linear-scan voltammetry

Citation: 'linear-scan voltammetry' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.09141 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for ...
openaire   +1 more source