Results 61 to 70 of about 403,825 (264)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Non-dispersive wavepackets generated in layered structures by a scanning laser source

AIP Advances, 2020
In this article, we describe the use of a continuous-wave laser scanning method to generate non-dispersive surface acoustic wavepackets, which propagate along the sample surface without any waveform change.
Zheng Li, Zhonghua Shen, Sridhar Krishnaswamy   +2 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

One microwave imaging system based on automotive radar chip

The Journal of Engineering, 2019
The interest in microwave imaging system is increasing because it can serve as a useful tool for concealed threat detecting. The current imaging systems have two major challenges: (i) multi-static arrays suffer from complex hardware design and ...
Fuwei Wu, Siming Li, Shize Shang, Yuanji Li, Yuhao Yang   +4 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Integrated circuits of self-scanning linear photodetectors in introscopy and tomography

Технологія та конструювання в електронній апаратурі, 2005
The results of designing and the characteristics of linear photosensitive devices (LPDs) based on active sensor cells and digital polling registers are presented.
V. L. Perevertaylo, A. A. Epifanov, V. G. Karengin, L. I. Таrаsеnkо, V. G. Karengin   +4 more
doaj  

The Influence of Process Parameters on the Density, Microstructure, and Mechanical Properties of TA15 Titanium Alloy Fabricated by Selective Laser Melting

Metals
With superior manufacturing freedom capability, Selective Laser Melting (SLM) technology is capable of fabricating high-strength Ti-6Al-2Zr-1Mo-1V (TA15) complex titanium alloy parts, thereby finding extensive applications in the aerospace sector.
Junjie Jiang, Chuang Liang, Yuanchao Chen, Yongbiao Wang, Hongyang Cui, Jianlin Xu, Fang Zhou, Pengpeng Wang, David Z. Zhang   +8 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source