Results 131 to 140 of about 9,853 (229)

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, Volume 13, Issue 34, 19 June 2026.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

Frontal linear scleroderma (en coup de sabre): A case report

, 2006
En coup de sabre is a type of linear scleroderma which presents on the frontal or frontoparietal scalp. En coup de sabre in children is associated with asymmetric growth and progressive facial disfigurement.

core  

A Cooperative Release of Mitochondrial DNA From Platelets and Neutrophils Drives an Interferon Signature in Systemic Sclerosis

Arthritis &Rheumatology, Volume 78, Issue 6, Page 1281-1293, June 2026.
Objective Mitochondria are organelles with a hypomethylated circular genome. Mitochondrial DNA (mtDNA) in the systemic circulation has been implicated in inflammation. This study investigates the role of circulating DNA in systemic sclerosis (SSc) and the cellular mechanisms governing its release.
Stavros Giaglis, André N. Tiaden, Simone Häner‐Massimi, Diego Kyburz, Cedric André, Anton Glück, Enrico Ferrero, Stuart Hawtin, Tobias Junt, Ulrich A. Walker   +9 more
wiley   +1 more source

Long‐Term Outcomes of Reduced‐Intensity Conditioning Hematopoietic Stem Cell Transplantation for Patients With Systemic Sclerosis With Impaired Cardiac Function

Arthritis &Rheumatology, Volume 78, Issue 6, Page 1294-1305, June 2026.
Objective High‐intensity conditioning autologous hematopoietic stem cell transplantation (AHSCT) is standard of care for patients with advanced systemic sclerosis (SSc). The role of reduced‐intensity conditioning (RIC) before AHSCT in this population remains unclear.
Yonatan Lean, Carrie Richardson, Anthony J. Esposito, Katy Bedjeti, George E. Georges   +4 more
wiley   +1 more source

Oxygen Supplementation Improves Oxygen Uptake Kinetics and Exercise Performance in PAH and CTEPH Patients

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
In patients with pulmonary vascular diseases (PAH and CTEPH), supplemental oxygen (FiO2 0.3), compared to room air (FiO2 0.21) improved peak exercise capacity (peak V̇O2), peak sustainable exercise (V̇O2 at GET), and V̇O2 kinetics and the onset of exercise.
Shir Kadosh, Yael Baidats, Andrew M. Jones, Daryl Wilkerson, Ariela Velner, Ronen Reuveny, Michael J. Segel   +6 more
wiley   +1 more source

Juvenile localized scleroderma: clinical and epidemiological features in 750 children. An international study [PDF]

, 2006
Juvenile localized scleroderma (JLS) includes a number of conditions often grouped together. With the long-term goal of developing uniform classification criteria, we studied the epidemiological, clinical and immunological features of children with JLS ...
MOORE TL, MACHADO C, ZULIAN F, PESERICO STECCHINI NEGRI DE SALVI, ANDREA, LINDSLEY C, ATHREYA BH, VAN SUIJLEKOM SMIT LW, FEITOSA DE OLIVEIRA SK, WOO P, NELSON AM, ESTEVES HILARIO MO, SILVA CA, UZIEL Y, HARPER J, GARCIA CONSUEGRA J, HIGGINS GC, JUVENILE SCLERODERMA WORKING GROUP OF THE PEDIATRIC RHEUMATOLOGY EUROPEAN SOCIETY PRES, CUTTICA R, MARTINI G, GARAY SM, PUNARO MG, LEPORE L, LAXER R, FOELDVARI I   +23 more
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Oral Lesions Developed in Post‐Hematopoietic Stem Cell Transplant Patients and the Role of Cryogun Cryotherapy

Clinical and Experimental Dental Research, Volume 12, Issue 3, June 2026.
ABSTRACT Objective To investigate the development of oral premalignant and malignant lesions as a major long‐term complication following hematopoietic stem cell transplantation. Methods This single‐center retrospective study identified 17 patients who developed 26 pathology‐confirmed oral premalignant and malignant lesions after hematopoietic stem cell
Pei Hsuan Lu, Kelly Yi Ping Liu, Samson P. Ng, Catherine F. Poh   +3 more
wiley   +1 more source

A Case of Linear Scleroderma En Coup de Sabre Accompanied with Migraine with Visual Aura and Idiopathic Intracranial Hypertension.

Indian J Dermatol, 2023
Semiz Y, Singer R, Topal IO, Ucler S, Yalcin O.   +4 more
europepmc   +1 more source

Immunotherapy‐Related Cutaneous Toxicities in Melanoma: A Dermoscopic Perspective

JEADV Clinical Practice, Volume 5, Issue 2, Page 402-414, June 2026.
Dermoscopy serves as a valuable tool in the everyday dermatological and oncological practice for melanoma patients, allowing for the prompt identification of immune‐related cutaneous toxicities and guiding clinicians toward appropriate therapeutic decisions.
Grażyna Kamińska‐Winciorek, Iris Zalaudek, Karolina Zarańska, Bożena Cybulska‐Stopa   +3 more
wiley   +1 more source

Twardzina ograniczona pęcherzowa – przedstawienie dwóch przypadków, trudności terapeutyczne

Przegląd Dermatologiczny, 2011
tissue disease. The main symptoms are atrophy and fibrosis of the connectivetissue stroma, preceded by changes in the small blood vessels.Pathogenesis of morphea is still unknown.
Dorota Krasowska, Aldona Pietrzak, Bartłomiej Wawrzycki, Joanna Gładysz, Grażyna Chodorowska, Katarzyna Kozłowicz   +5 more
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