Biorelevant Drug Solubility Enhancement Modeled by a Linear Solvation Energy Relationship [PDF]
Journal of Pharmaceutical Sciences, 2018 It is for the pharmaceutical sciences of vital importance to understand how drugs are solubilized in biorelevant media. However, the complexity of fasted state simulated intestinal fluid (FaSSIF) has so far hampered adequate solubility modeling. The present study focuses on apparently neutral compounds at physiological pH and a linear free energy ...
Niederquell A, Kuentz M
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A model for specific interactions of manganese-phthalocyanine in protic media
Eclética Química, 2018 Extinction coefficients (e) changes of manganese phthalocyanine (Mn-Pc) were studied in different organic solvents and related to solvent polarity scales (Kosower's values (Z), Dimroth's values (ET), donor numbers (DN) and linear solvation energy ...
Nadir Ana WIEDERKEHR
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Synthesis and solvatochromism of some hydroxy substituted phenyl azo pyridone dyes
Zaštita Materijala, 2023 Aryl azo dyes are widely used due to their excellent physicochemical properties (primarily high value of the molar extinction coefficient and great resistance to light and wet processing) and the fact that can be obtained in a simple method of ...
Đenđi Vaštag, Dušan Mijin
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Solvent influence on absorption spectra of food azo dyes
Zaštita Materijala, 2019 The solvent influence on absorption spectra of food azo dyes was examined by the method of Linear Solvation Energy Relationships (LSER). For this purpose, six azo dyes were used: tartrazine (E 102), ponceau 4R (E 124), azorubin (E 122), brilliant black ...
Nebojša Banjac, Nemanja Trišović
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First-Principles-Based Optimized Design of Fluoride Electrolytes for Sodium-Ion Batteries
Molecules, 2022 Because of the abundance and low cost of sodium, sodium-ion batteries (SIBs) are next-generation energy storage mediums. Furthermore, SIBs have become an alternative option for large-scale energy storage systems.
Shuhan Lu +7 more
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FTIR investigation of solvent-induced carbonyl band shifts of 17β-hydroxy-17α-picolyl-androst-4-en-3-one [PDF]
Acta Periodica Technologica, 2014 Polar functional groups in the A- and D-ring (positions C-3 and C-17) are common for the most of natural and synthetic steroid hormones. It is assumed that these pharmacophoric groups are involved in the strong hydrogen bonding interactions with
Jović Branislav D. +3 more
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Rapid determination of serum albumin partition coefficients using affinity chromatography
Environmental Advances, 2022 Sorption to serum albumin is essential for characterizing the distribution of chemicals in organisms. It impacts the concentration of the freely dissolved chemical in vivo and in vitro, and needs to be considered when effect concentrations at the target ...
Nadin Ulrich, Alexander Böhme
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Solubility data and solubility parameters of barnidipine in different pure solvents
Ars Pharmaceutica, 2023 Introduction: Solubility studies and obtaining physicochemical data on drugs in pure solvents belonging to different chemical classes are key to developing new drug formulations.
Mª Ángeles Peña-Fernández +3 more
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Solvatochromism of 5-(4-substituted arylazo)-4-phenyl-6-methyl-3-cyano-2-pyridones
Zaštita Materijala, 2018 Eight 5-(4-substituted arylazo)-4-phenyl-6-methyl-3-cyano-2-pyridones were synthesized by reaction of benzoylacetone and arendiazonium salt, followed by condensation with cyanoacetamide. Absorption spectra of all azo pyridone dyes were recorded in twelve
Gordana S. Ušćumlić +1 more
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