Results 111 to 120 of about 11,397,498 (302)
Structured Stochastic Linear Bandits
CoRR, 2016 The stochastic linear bandit problem proceeds in rounds where at each round the algorithm selects a vector from a decision set after which it receives a noisy linear loss parameterized by an unknown vector. The goal in such a problem is to minimize the (pseudo) regret which is the difference between the total expected loss of the algorithm and the ...
Nicholas Johnson 0001 +2 more
openaire +2 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Analysis of a new front-end structure offset impact: mass-spring-damper models with piecewise linear characteristics [PDF]
, 2010 In this paper, new front-end structures (smart) are proposed to improve vehicle frontal impact. The work carried out in this paper includes developing and analysing mathematical models of vehicle-to-rigid barrier offset frontal impact using fixed and ...
Elmarakbi, Ahmed, Ahmed Elmarakbi
core +1 more source
STRUCTURAL LINEARITY AND NON-LINEARITY. [PDF]
International Journal of Advanced Research, 2017 VaibhvP Karnik +2 more
openaire +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Linear structure taxonomy with the account of environmental polystructures impact
MATEC Web of Conferences, 2018 One of the specific features of transportation facilities design is the necessity to account changing environmental conditions in considerable distances along the track.
Bobrova Tatyana, Vorobyev Valeriy
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Non-Linear Seismic Analysis Method of Concrete Frame Structure [PDF]
Bulletin of the Polytechnic Institute of Jassy: Constructions, Architechture Section, 2005 The proposed computation method principle utilized in the studied problem, which consist in solving the dynamic equilibrium differential equation system, written in the incremental form, using a hysteretic model of computing in analytical form, is ...
V. Filip, Felix Schärf
doaj