Results 211 to 220 of about 1,361,387 (267)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Linear and Angular Deviations of Complete-Arch Digital Implant Impressions Using Three Scan Body Systems: An In Vitro Study. [PDF]

Dent J (Basel)
Blivajs I, Smojver I, Reiser Y, Jurić S, Hadžović E, Pelivan I, Gabrić D.   +6 more
europepmc   +1 more source

Performance and Interaction Mechanisms of Bitumen Modified with Devulcanized Rubber-Recycled Polymer Composites. [PDF]

Polymers (Basel)
Bussurmanova A, Akkenzheyeva A, Yensegenova U, Haritonovs V, Eida G, Bernava A, Kornisovs R, Imanbayev Y, Turkmenbayeva M, Urbonavicius P, Aimova M, Ayapbergenov Y, Jankauskas M.   +12 more
europepmc   +1 more source

Precision Trajectory Tracking of Magnetically Actuated Microparticles Using Permanent-Magnet Systems Under State Constraints. [PDF]

Micromachines (Basel)
Hamdaoui ZE, Wang S, Boutat D, Barbri NE, Rhofir K.   +4 more
europepmc   +1 more source

Linear complementarity systems

, 1997
Heemels, W.P.M.H., Schumacher, J.M., Weiland, S.   +2 more
openaire   +2 more sources

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Fuzzy Linear Systems

Fuzzy Sets and Systems, 1998
Fuzzy linear systems were considered by many authors [cf. e.g. \textit{R. Fullér}, Fuzzy Sets Syst. 34, No. 3, 347-353 (1990; Zbl 0696.15003); \textit{R. Zhao} and \textit{R. Govind}, Inf. Sci. 56, No. 1-3, 199-243 (1991; Zbl 0726.65048); \textit{J. J. Buckley, T. Feuring} and \textit{Y. Hayashi}, Int. Ser. Intell. Technol.
Menahem Friedman, Abraham Kandel, Ma Ming   +2 more
exaly   +4 more sources

Systems Of Linear Congruences

Canadian Journal of Mathematics, 1955
1. Introduction. On recent occasions papers have been presented concerned with the problem of solving a system of linear congruences. Apparently the authors were not aware that this problem was solved very neatly and completely a long time ago by H. J. S. Smith (5; 6).
Butson, A. T., Stewart, B. M.
openaire   +1 more source

Linear systems on graphs

2016 IEEE Global Conference on Signal and Information Processing (GlobalSIP), 2016
Many interesting ideas relating to signal processing on graphs have evolved in recent years. This paper visits some basic properties in linear system theory that have not been addressed in the context of graphs. In classical discrete-time system theory, a linear system is shift-invariant if and only if it can be described using a “polynomial” transfer ...
Oguzhan Teke, P. P. Vaidyanathan
openaire   +1 more source