Results 231 to 240 of about 5,206,394 (288)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Hamiltonian simulation for nonlinear partial differential equation by Schrödingerization. [PDF]

Sci Rep
Sasaki S, Endo K, Muramatsu M.
europepmc   +1 more source

Intrinsic Quantization of Linear Hamiltonian Systems. [PDF]

Entropy (Basel)
Accardi L, Pandiscia C.
europepmc   +1 more source

Two-Temperature and Thermal Plasma Kinetic Theories. [PDF]

Entropy (Basel)
Giovangigli V.
europepmc   +1 more source

Anomalous Coulomb-Enhanced Charge Transport in Triangular Triple-Quantum-Dot Systems. [PDF]

Entropy (Basel)
Dong S, Li J, Wei J.
europepmc   +1 more source

Linear complementarity systems

, 1997
Heemels, W.P.M.H., Schumacher, J.M., Weiland, S.   +2 more
openaire   +2 more sources

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Fuzzy linear systems

Fuzzy Sets and Systems, 1998
Fuzzy linear systems were considered by many authors [cf. e.g. \textit{R. Fullér}, Fuzzy Sets Syst. 34, No. 3, 347-353 (1990; Zbl 0696.15003); \textit{R. Zhao} and \textit{R. Govind}, Inf. Sci. 56, No. 1-3, 199-243 (1991; Zbl 0726.65048); \textit{J. J. Buckley, T. Feuring} and \textit{Y. Hayashi}, Int. Ser. Intell. Technol.
Menahem Friedman, Ming Ma 0001, Abraham Kandel   +2 more
openaire   +2 more sources

Uncertain linear systems

Fuzzy Optimization and Decision Making, 2014
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Bo Li 0050, Yuanguo Zhu
openaire   +2 more sources