Results 191 to 200 of about 544,687 (266)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Identifiable learning of dissipative dynamics. [PDF]

Nat Commun
Zhu A, Soh BW, Pavliotis GA, Li Q.
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Bio-Inspired Controller Design via Dholes-Inspired Optimization: A Novel Gompertz Function-Augmented PID Strategy for Electro-Hydraulic Actuator Control. [PDF]

Biomimetics (Basel)
Güngör Mİ, Izci D, Ekinci S.
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Trajectory tracking control of unmanned aerial vehicle with disturbance observer and robust adaptive neural dynamic surface. [PDF]

PLoS One
Pan X, Wang D, Liu Y, Nan X.
europepmc   +1 more source

A simplified and highly efficient cell-free protein synthesis system for prokaryotes. [PDF]

Elife
Lang X, Zhang C, Lin J, Zhang Z, Li W.
europepmc   +1 more source

Elucidating the origin of decoupling in glass-forming liquids through high-temperature activation free energies. [PDF]

Natl Sci Rev
Yuan QL, Dong YT, Yang Z, Douglas JF, Starr FW, Sun ZY, Xu WS.   +6 more
europepmc   +1 more source