Results 101 to 110 of about 58,035 (315)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Linearization conditions for regression models with unknown variance parameter [PDF]

open access: yes, 2000
summary:In the case of the nonlinear regression model, methods and procedures have been developed to obtain estimates of the parameters. These methods are much more complicated than the procedures used if the model considered is linear.
Jenčová, Anna
core   +1 more source

Optimization of the transition function of a modular uninterruptible power supply slave type

open access: yesФизика волновых процессов и радиотехнические системы, 2015
The system uninterruptible power supply with an output voltage sine wave used several parallel-connected uninterruptible power supplies. In the linearized model output inverter delay is not taken into account the phase of the output signal pulse - width ...
A.E. Geytenko, E.N. Geytenko
doaj  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Gain-Scheduled Disturbance Observer-Based Saturated Controllers for Non-Linear First-Order System

open access: yesApplied Sciences
Almost a century ago, the first industrial controllers were introduced to the market, labeled as automatic reset and later generalized to hyper-reset or pre-act.
Mikulas Huba   +2 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Conditions on Cyclic Linearization [PDF]

open access: yes, 2019
Article信州大学総合人間科学研究 13 : 75-87(2019)departmental bulletin ...
田口, 茂樹
core  

The Optimal Operating Point for Linearizing an Integrated Optical Lithium Niobate Directional Coupler Modulator

open access: yesPhotonics
The influence of an operating point on the linearity of an integrated optical lithium niobate directional coupler modulator was studied. It was found that the optimal setting for the position of an operating point for suppressing the third-order ...
Peter Agruzov   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Distortion components iterative injection technique for linearization of power amplifiers

open access: yes, 2009
This paper presents a new technique for linearization of power amplifiers based on the developed iteration algorithm for predistortion of I and Q signals.
Budimir, D.   +2 more
core  

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