Results 101 to 110 of about 28,926 (266)
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
IEEE AccessIn this paper, we propose a scalable approximate multiplier design, scaleTRIM, that approximates the multiplication operation using fitted linear functions, also referred to as linearization.
Ebrahim Farahmand +6 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
IEEE Transactions on Machine Learning in Communications and NetworkingThis article presents a new box-oriented framework and training strategy that integrates conventional models with neural networks (NNs) for accurate power amplifier (PA) behavioral modeling and digital predistortion (DPD).
Lesthuruge Silva +4 more
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Linear Characters of Finite Linear Groups
Journal of Algebra, 1999 Let \(V\) be a vector space of dimension \(n\) over the field \(\mathbb{F}_q\) of order \(q\), let \(G\) be a subgroup of \(\text{GL}(V)\), and let \(Y\) be a \(G\)-invariant subset of the set \({\mathcal P}(V)\) of \(1\)-spaces of \(V\). The author defines an \(\mathbb{F}_q^*\)-valued linear character \(\delta_Y\) related to the permutation action of \
openaire +2 more sources
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Characterization of Isoclinic, Transversally Geodesic and Grassmannizable Webs
AxiomsOne of the most relevant topics in web theory is linearization. A particular class of linearizable webs is the Grassmannizable web. Akivis gave a characterization of such a web, showing that Grassmannizable webs are equivalent to isoclinic and ...
Jihad Saab, Rafik Absi
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Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source