Results 111 to 120 of about 58,035 (315)

α-Hölder Linearization

, 1998
A well known theorem of Hartman and Grobman says that aC2diffeomorphismf:Rn→Rnwith a hyperbolic fixed point at 0 can be topologically conjugated to the linear diffeomorphismL=df(0) (in a neighborhood of 0).
Rayskin, Victoria
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Algorithmic Transverse Feedback Linearization [PDF]

, 2022
The feedback equivalence problem, that there exists a state and feedback transformation between two control systems, has been used to solve a wide range of problems both in linear and nonlinear control theory.
D'Souza, Rollen
core  

Linear Estimation for Approximately Linear Models

The Annals of Statistics, 1978
An approximate linear model is proposed to allow for deviations from an underlying ideal linear model as follows: If, in standard notation, $Y = A\beta + \varepsilon$ is the ideal model then $Y = A\beta + r + \varepsilon$ where $|r_i| \leqq M_i$ for $M$ a given vector is an approximate linear model.
Sacks, Jerome, Ylvisaker, Donald
openaire   +3 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Linear Filters and Non-Linear Systems

Journal of the Royal Statistical Society Series B: Statistical Methodology, 1992
SUMMARY It has been asserted in the literature that the low pass filtering of time series data may lead to erroneous results when calculating attractor dimensions. Here we prove that finite order, non-recursive filters do not have this effect. In fact, a generic, finite order, non-recursive filter leaves invariant all the quantities that
Broomhead, D. S., Huke, J. P., Muldoon, M. R.   +2 more
openaire   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Linearization of hybrid processes

, 2006
HyPA is a formalism that is suitable for the algebraic analysis of hybrid systems, i.e., systems with continuous (physical) as well as discrete (computational) components.
Reniers, M.A.; id_orcid, Reniers, M.A., Cuijpers, P.J.L., Cuijpers, P.J.L.; id_orcid, den Brand, P.C.W., Brand, van den, P.C.W.   +5 more
core   +1 more source

Generalized Quadratic Linearization of Machine Models [PDF]

, 2011
In the exact linearization of involutive nonlinear system models, the issue of singularity needs to be addressed in practical applications. The approximate linearization technique due to Krener, based on Taylor series expansion, apart from being ...
Kamaraj Vijayarajan, Devanathan Rajagopalan, Parvathy Ayalur Krishnamoorthy   +2 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source