Results 91 to 100 of about 854,945 (303)

Targeted Degradation of eEF2K by a Structure‐Guided PROTAC Strategy for the Treatment of Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
This study developed an eEF2K‐targeting PROTAC, A6, that efficiently degrades eEF2K in TNBC cells, inhibiting tumor growth in vitro and in vivo. To enhance tumor‐specific delivery, we engineered A6@ZIF‐8, a pH‐sensitive nanocarrier, which improved drug accumulation at tumor sites, offering a promising therapeutic strategy for TNBC through targeted ...
Shijun Cao   +10 more
wiley   +1 more source

Linguistic Means of Reflecting Social Differences in British Press

open access: yesVestnik MGIMO-Universiteta, 2012
The article deals with the main tendencies of modern British newspaper language addressed to readers with different background. Comparing texts in «quality» newspapers and «middlebrow» tabloids allows to reveal linguistic means differing according to ...
V. V. Ignatenko
doaj   +1 more source

Compensatory Interplay Between Clarin‐1 and Clarin‐2 Deafness‐Associated Proteins Governs Phenotypic Variability in Hearing

open access: yesAdvanced Science, EarlyView.
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling   +17 more
wiley   +1 more source

Modulating Persistent Photoconductivity through Barrier Engineering for High‐performance and Multifunctional Two‐dimensional Optoelectronic Devices

open access: yesAdvanced Science, EarlyView.
Schottky barrier engineering using van der Waals contacts enables effective modulation of persistent photoconductivity (PPC) in optoelectronic devices. A high persistent photoconductivity gain (PPCG) (307.6%) is achieved in a high‐barrier Au/MoS2 junction, supporting photomemory and optoelectronic synaptic behaviors. A low PPCG (4.72%) is achieved in a
Panpan Huo   +8 more
wiley   +1 more source

Linguistic Means of Russia’s Image Making in Modern Advertising

open access: yesRUDN Journal of Language Studies, Semiotics and Semantics, 2017
The article is devoted to description of the linguistic features specific means of Russia’s image making in modern TV advertising. Linguistic issue of the image is to study the concept, distinguish it from certain closely related concepts and also to use
Elena Nikolaevna Remchukova   +1 more
doaj   +1 more source

"Kiezdeutsch goes School" : a multiethnic variety of German from an educational perspective [PDF]

open access: yes, 2008
This article presents linguistic features of and educational approaches to a new variety of German that has emerged in multi-ethnic urban areas in Germany: Kiezdeutsch (‘Hood German’).
Freywald, Ulrike   +2 more
core  

The Role of Actual and Purported Origin in e‐Commerce Wine Pricing: Evidence From Italian and French Names on Labels

open access: yesAgribusiness, EarlyView.
ABSTRACT The origin of a product, if associated with good quality, can contribute to building a positive collective reputation, leading to a potential price premium. However, it is conceivable that a producer markets a product by evoking symbols, images, words, and values typical of places other than where it was designed or produced, creating a ...
Annalisa Caloffi   +2 more
wiley   +1 more source

Generating a 3D Simulation of a Car Accident from a Written Description in Natural Language: the CarSim System [PDF]

open access: yes, 2001
This paper describes a prototype system to visualize and animate 3D scenes from car accident reports, written in French. The problem of generating such a 3D simulation can be divided into two subtasks: the linguistic analysis and the virtual scene ...
Dupuy, Sylvain   +3 more
core   +2 more sources

Consumer Preferences for Craft Beer: The Interplay of Localness and Advertising Language

open access: yesAgribusiness, EarlyView.
ABSTRACT This study explores the influence of the language of the label, origin of production, and origin of brewing ingredients on Croatian consumers' preferences and willingness to pay for organic craft beer. Employing an online survey and a choice experiment among 223 Croatian alcohol consumers, we find that while there's a willingness to pay a ...
Marija Cerjak   +2 more
wiley   +1 more source

Reader Contact in Advertising Discourse [PDF]

open access: yes, 2010
To establish physical, emotional, and mental contact with the reader, press advertising writers use a variety of linguistic and paralinguistic techniques which deal with pictures, type and size of letters, the properties and relations of objects and ...
Котнюк, Л. Г.
core  

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