Results 51 to 60 of about 4,205 (281)

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Stable routing protocol for unmanned aerial vehicle ad‐hoc networks based on DQN‐OLSR

IET Communications, 2023
In unmanned aerial vehicle ad‐hoc network (UANET), the network topology changes with time due to the movement of the unmanned aerial vehicles (UAVs), which brings great challenges to the design of the routing protocol.
Youjun Zeng, Jie Zhou, Youjiang Liu, Tao Cao, Dalong Yang, Yu Liu, Xianhua Shi   +6 more
doaj   +1 more source

Comparative Analysis of OLSR and DSR Routing Protocol Performance on Vehicular Ad Hoc Network (VANET)

Simetris: Jurnal Teknik Mesin, Elektro dan Ilmu Komputer, 2023
Communication between vehicles is essential in increasing comfort and safety for drivers and passengers. Technology advancements offer a new concept: the Vehicular Ad Hoc Network (VANET).
Ery Safrianti, Linna Oktaviana Sari, Ahmad Romadan, Feranita Feranita   +3 more
doaj   +1 more source

Genetic diversity and population structure of the Taigan dog breed

FEBS Open Bio, EarlyView.
The Taigan is a rare sighthound from the mountains of Kyrgyzstan. We used DNA markers to study its genetic diversity and compare it with other sighthound breeds. Our findings show that the Taigan shares close genetic ties with the Kazakh Tazy, suggesting a common ancestry shaped by nomadic traditions and regional adaptation.
Kira Bespalova, Anastassiya Perfilyeva, Мamura Begmanova, Assel Zhaxylykova, Arailym Yerzhan, Kanagat Yergali, Almazbek Akunov, Marat Munarbek uulu, Anna Khamchukova, Almira Amirgaliyeva, Yelena Kuzovleva   +10 more
wiley   +1 more source

A review of forest fire surveillance technologies: Mobile ad-hoc network routing protocols perspective

Journal of King Saud University: Computer and Information Sciences, 2019
Mobile Ad-Hoc Network (MANET) is a type of structure-less wireless mobile network, in which each node plays the role of the router and host at the same time.
Fahad Taha AL-Dhief, Naseer Sabri, S. Fouad, N.M. Abdul Latiff, Musatafa Abbas Abbood Albader   +4 more
doaj  

Phenotypic plasticity in a novel set of EGFR tyrosine kinase inhibitor‐adapted non‐small cell lung cancer cell lines

FEBS Open Bio, EarlyView.
Phenotypic plasticity in a newly established set of EGFR inhibitor‐adapted NSCLC cell lines during adaptation and in established cell lines. Here, we introduce novel sublines of the EGFR‐mutant non‐small cell lung cancer (NSCLC) cell lines HCC827 and HCC4006 adapted to the EGFR kinase inhibitors gefitinib (HCC827rGEFI2μm, HCC4006rGEFI1μm), erlotinib ...
Tharsagini V. Nanthaprakash, Campbell W. Gourlay, Ina Oehme, Michelle D. Garrett, Jindrich Cinatl Jr, Mark N. Wass, Martin Michaelis   +6 more
wiley   +1 more source

Adaptive mobility-aware and reliable routing protocols for healthcare vehicular network

Mathematical Biosciences and Engineering, 2022
Healthcare vehicles such as ambulances are the key drivers for digital and pervasive remote care for elderly patients. Thus, Healthcare Vehicular Ad Hoc Network (H-VANET) plays a vital role to empower the digital and Intelligent Transportation System ...
Nawaz Ali Zardari, Razali Ngah , Omar Hayat, Ali Hassan Sodhro   +3 more
doaj   +1 more source

Avoiding Transient Loops During the Convergence of Link-State Routing Protocols

IEEE/ACM Transactions on Networking, 2007
When using link-state protocols such as OSPF or IS-IS, forwarding loops can occur transiently when the routers adapt their forwarding tables as a response to a topological change. In this paper, we present a mechanism that lets the network converge to its optimal forwarding state without risking any transient loops and the related packet loss.
François, Pierre, Bonaventure, Olivier
openaire   +3 more sources

Placebo Effect Sizes in Clinical Trials of Knee Osteoarthritis Using Intra‐Articular Injections of Biologic Agents

Arthritis Care &Research, EarlyView.
Objective Patients with knee osteoarthritis rely on symptomatic treatments, in which up to 75% of the pain reduction can be attributed to the placebo effect. This effect may vary based on treatment type (eg, biologics vs nonbiologic injection) and route of administration (eg, intra‐articular vs topical vs oral).
Johanna M. Borst, Severin Ruoss, Ian Palmer, Trevor Smith, Kenneth Kalunian, Samuel R. Ward   +5 more
wiley   +1 more source