Results 71 to 80 of about 158,887 (283)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Lightweight Routing Protocol for Named Data Networking [PDF]

Jisuanji kexue yu tansuo
Named data networking (NDN) is a novel network architecture that revolves around information-centric principles. In order to acquire global routing information within the network, typical NDN routing protocols rely on data synchronization mechanisms to ...
ZOU Bowen, SONG Tian, LI Tianlong, YANG Yating
doaj   +1 more source

Routing over QUIC: Bringing transport innovations to routing protocols [PDF]

arXiv, 2023
By combining the security features of TLS with the reliability of TCP, QUIC opens new possibilities for many applications. We demonstrate the benefits that QUIC brings for routing protocols. Current Internet routing protocols use insecure transport protocols. BGP uses TCP possibly with authentication. OSPF uses its own transport protocol above plain IP.
arxiv  

Optimized Link State Routing Protocol Version 2 (OLSRv2) and MANET Neighborhood Discovery Protocol (NHDP) Extension TLVs

Request for Comments, 2014
This specification describes extensions to definitions of TLVs used by the Optimized Link State Routing Protocol version 2 (OLSRv2) and the MANET Neighborhood Discovery Protocol (NHDP) to increase their abilities to accommodate protocol extensions.
C. Dearlove, T. Clausen
semanticscholar   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Routing in IPv6 over Low-Power Wireless Personal Area Networks (6LoWPAN): A Survey

Journal of Computer Networks and Communications, 2012
6LoWPANs (IPv6-based Low-Power Personal Area Networks) are formulated by devices that are compatible with the IEEE 802.15.4 standard. To moderate the effects of network mobility, the Internet Protocol (IP) does not calculate routes; it is left to a ...
Vinay Kumar, Sudarshan Tiwari
doaj   +1 more source

Performance and Improvement Analysis of the Underwater WSN Using a Diverse Routing Protocol Approach

Journal of Computer Networks and Communications, 2022
The planet Earth is the most water-rich place because oceans cover more than 75% of its land area. Because of the extraordinary activities that occur in the depths, we know very little about oceans.
K. Sathish, C. V. Ravikumar, Asadi Srinivasulu, A. Rajesh, Olutayo Oyeyemi Oyerinde   +4 more
doaj   +1 more source

Routing Path Assignment for Joint Load Balancing and Fast Failure Recovery in IP Network

Applied Sciences, 2021
Distributed link-state routing protocols, including Open Shortest Path First (OSPF) and Intermediate System–Intermediate System (IS-IS), have successfully provided robust shortest path routing for IP networks. However, shortest path routing is inflexible
Tabinda Ashraf, Steven S. W. Lee, Muhammad Iqbal, Jen-Yi Pan   +3 more
doaj   +1 more source

Comparative activity of dimethyl fumarate derivative IDMF in three models relevant to multiple sclerosis and psoriasis

FEBS Open Bio, EarlyView.
IDMF is a derivative of dimethyl fumarate (DMF) with a unique therapeutic potential at the intersection of psoriasis and multiple sclerosis. Here, we demonstrate that it compares favorably with DMF and its other derivatives, such as Diroximel, in the zebrafish, microglia, and lymphocyte models.
Yulin He, Guiyi Gong, Geovani Quijas, Simon Ming‐Yuen Lee, Ratan K. Chaudhuri, Krzysztof Bojanowski   +5 more
wiley   +1 more source

Simulation and Performance Analysis of MP-OLSR for Mobile Ad hoc Networks [PDF]

, 2008
Mobile ad hoc networks (MANETs) consist of a collection of wireless mobile nodes which dynamically exchange data without reliance on a fixed base station or a wired backbone network, which makes routing a crucial issue for the design of a ad hoc networks.
Cizeron, Eddy, Hamma, Salima, Parrein, Benoît, Yi, Jiazi   +3 more
core   +2 more sources