Results 81 to 90 of about 166,291 (365)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Routing in IPv6 over Low-Power Wireless Personal Area Networks (6LoWPAN): A Survey

Journal of Computer Networks and Communications, 2012
6LoWPANs (IPv6-based Low-Power Personal Area Networks) are formulated by devices that are compatible with the IEEE 802.15.4 standard. To moderate the effects of network mobility, the Internet Protocol (IP) does not calculate routes; it is left to a ...
Vinay Kumar, Sudarshan Tiwari
doaj   +1 more source

Performance and Improvement Analysis of the Underwater WSN Using a Diverse Routing Protocol Approach

Journal of Computer Networks and Communications, 2022
The planet Earth is the most water-rich place because oceans cover more than 75% of its land area. Because of the extraordinary activities that occur in the depths, we know very little about oceans.
K. Sathish, C. V. Ravikumar, Asadi Srinivasulu, A. Rajesh, Olutayo Oyeyemi Oyerinde   +4 more
doaj   +1 more source

Routing over QUIC: Bringing transport innovations to routing protocols [PDF]

arXiv, 2023
By combining the security features of TLS with the reliability of TCP, QUIC opens new possibilities for many applications. We demonstrate the benefits that QUIC brings for routing protocols. Current Internet routing protocols use insecure transport protocols. BGP uses TCP possibly with authentication. OSPF uses its own transport protocol above plain IP.
arxiv  

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Multi-Topology Extension for the Optimized Link State Routing Protocol Version 2 (OLSRv2)

Request for Comments, 2015
This specification describes an extension to the Optimized Link State Routing Protocol version 2 (OLSRv2) to support multiple routing topologies, while retaining interoperability with OLSRv2 routers that do not implement this extension.
C. Dearlove, T. Clausen
semanticscholar   +1 more source

Routing Path Assignment for Joint Load Balancing and Fast Failure Recovery in IP Network

Applied Sciences, 2021
Distributed link-state routing protocols, including Open Shortest Path First (OSPF) and Intermediate System–Intermediate System (IS-IS), have successfully provided robust shortest path routing for IP networks. However, shortest path routing is inflexible
Tabinda Ashraf, Steven S. W. Lee, Muhammad Iqbal, Jen-Yi Pan   +3 more
doaj   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Simulation and Performance Analysis of MP-OLSR for Mobile Ad hoc Networks [PDF]

, 2008
Mobile ad hoc networks (MANETs) consist of a collection of wireless mobile nodes which dynamically exchange data without reliance on a fixed base station or a wired backbone network, which makes routing a crucial issue for the design of a ad hoc networks.
Cizeron, Eddy, Hamma, Salima, Parrein, Benoît, Yi, Jiazi   +3 more
core   +2 more sources

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source