Results 91 to 100 of about 4,725,478 (361)

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Study of kerf geometry of multilayers materials in abrasive water jet cutting process

MATEC Web of Conferences, 2017
The use of abrasive jet cutting in case of multilayers materials, shows particularities and difficulties, due to different hardness and thickness of layers.
Barabas Bogdan, Deaconescu Andrea
doaj   +1 more source

Generalized $1$-harmonic Equation and The Inverse Mean Curvature Flow

, 2010
We introduce and study generalized $1$-harmonic equations (1.1). Using some ideas and techniques in studying $1$-harmonic functions from [W1] (2007), and in studying nonhomogeneous $1$-harmonic functions on a cocompact set from [W2, (9.1)] (2008), we ...
Ai-Nung Wang, Bombieri, Bray, Calabi, Cheeger, Chen, Demengel, Evans, Federer, Huisken, Kawohl, Kotschwar, Lin, Moser, Shihshu Walter Wei, Wang, Wei, Wei, Wei, Yau, Yng-Ing Lee   +20 more
core   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

cis-Dichloridobis(N,N,N′,N′-tetramethylethane-1,2-diamine)platinum(II)

Acta Crystallographica Section E, 2012
In the title complex, [PtCl2(C6H16N2)], the PtII atom adopts a distorted cis-PtN2Cl2 square-planar coordination geometry. The five-membered chelate ring adopts a twisted conformation.
Abdullah M. Asiri, Muhammad Nadeem Arshad, Muhammad Ishaq, Khalid A. Alamry, Tanveer Hussain Bokhari   +4 more
doaj   +1 more source

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

Ideal Hopf-link mode in phonon material Ba2OsH6

JPhys Materials
Phonon systems have emerged as potential platforms for exploring nontrivial band topologies. Meanwhile, two (or more) closed nodal lines (CNLs) may nest with each other and form a Hopf-link mode in momentum space.
Jianhua Wang, Weizhen Meng, Wenhong Wang, Zhenxiang Cheng, Shifeng Qian, Xiaotian Wang   +5 more
doaj   +1 more source

Optimum Choice of the Front Suspension of an Automobile

Журнал інженерних наук, 2019
The paper details the optimum choice of the front suspension of an automobile. The influence of suspension on the steering geometry is studied by considering the various combinations of joints at the four-bar mechanism of the front suspension.
Belkhode P. N.
doaj   +1 more source

Geometric Description of Schr\"{o}dinger Equation in Finsler and Funk Geometry

, 2019
For a system of $n$ non-relativistic spinless bosons, we show by using a set of suitable matching conditions that the quantum equations in the pilot-wave limit can be translated into a geometric language for a Finslerian manifold.
Bashir, Asma, Koch, Benjamin, Wasay, Muhammad Abdul   +2 more
core   +1 more source