Results 71 to 80 of about 71,077 (260)

Chloridotris(3,5-dimethyl-1H-pyrazole-κN2)(formato-κO)copper(II)–dichloridobis(3,5-dimethyl-1H-pyrazole-κN2)copper(II) (2/1)

Acta Crystallographica Section E, 2011
The asymmetric unit of the title compound, [Cu(CHO2)Cl(C5H8N2)3]2·[CuCl2(C5H8N2)2] or 2[A]·[B], contains one A molecule and one half-molecule of B, located on a centre of inversion. The CuII environments in A and B are different.
Yuliya M. Davydenko, Igor O. Fritsky, Vadim O. Pavlenko, Franc Meyer, Sebastian Dechert   +4 more
doaj   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Helicity, linking, and writhe in a spherical geometry

Journal of Physics: Conference Series, 2014
Linking numbers, helicity integrals, twist, and writhe all describe the topology and geometry of curves and vector fields. The topology of the space the curves and fields live in, however, can affect the behaviour of these quantities. Here we examine curves and fields living in regions exterior to a sphere or in spherical shells.
Campbell, Jack, Berger, M.A.
openaire   +2 more sources

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

Sarilumab in Polyarticular‐Course Juvenile Idiopathic Arthritis: Dose‐Finding and 1‐Year Analysis of a Phase 2b, Open‐Label, Multicenter Study

Arthritis Care &Research, EarlyView.
Objective This study assessed sarilumab in treating patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods This phase 2b, open‐label study (NCT02776735) consisted of three sequential parts (each with a core‐treatment and extension phase).
Fabrizio De Benedetti, Inmaculada C. Penadés, Irina Nikishina, Ivan Foeldvari, Alberto J. Spindler, Anna Kozlova, Nadina Rubio‐Pérez, Pierre Quartier, Zbigniew Żuber, Raul Barria, Daniel Clemente, Gabriel V. Cornejo, Katherine Marzan, Nancy Liu, Christine Xu, Stephen DiMartino, Angeliki Giannelou, Fei Cao‐Ghoul, Bolanle Akinlade, Lydie Baret‐Cormel   +19 more
wiley   +1 more source

Chen’s Ricci inequalities and topological obstructions on null hypersurfaces of a Lorentzian manifold

Journal of Inequalities and Applications, 2018
Given a null hypersurface of a Lorentzian manifold, we isometrically immerse a null hypersurface equipped with the Riemannian metric (induced on it by the rigging) into a Riemannian manifold suitably constructed on the Lorentzian manifold.
Karimumuryango Ménédore
doaj   +1 more source

Pharmacokinetics, Pharmacodynamics, and Safety of Subcutaneous Belimumab in Pediatric Patients With Systemic Lupus Erythematosus: A Multicenter, Open‐Label Trial

Arthritis Care &Research, EarlyView.
Objective This study aimed to characterize the pharmacokinetics, pharmacodynamics, safety, and exploratory efficacy of subcutaneous belimumab in pediatric patients with active systemic lupus erythematosus (SLE) receiving standard therapy. Methods This single‐arm, multicenter, open‐label trial (GSK study 200908; ClinicalTrials.gov identifier ...
Hermine I. Brunner, Jordi Antón, Inmaculada Calvo‐Penadés, Richard Dimelow, Gerd Horneff, Sylvia Kamphuis, Rebecca Marino, Andre van Maurik, Kirsten Minden, Masaaki Mori, Josephine Ocran‐Appiah, Christel Wilkinson, Yuichi Yamasaki, Deepak Assudani, for the Pediatric Rheumatology Collaborative Study Group (PRCSG) and Paediatric Rheumatology International Trials Organisation (PRINTO) Network investigators   +14 more
wiley   +1 more source

Bis(2-aminopyrimidine-κN1)dibromidozinc(II)

Acta Crystallographica Section E, 2008
The title compound, [ZnBr2(C4H5N3)2], is a mononuclear complex in which the ZnII ions have distorted tetrahedral coordination geometry. The ZnII ion binds to two N atoms from two different 2-aminopyrimidine ligands and two bromide ions.
Zhi Dong Lin, Huan Zhang, Xian Zong Wu, Shi Ming Zhang, Yang Qu   +4 more
doaj   +1 more source

Does Long‐Term Lower Extremity Strength Training in Adults With Knee Osteoarthritis and Varus Alignment Reduce Knee Joint Loading During Gait?

Arthritis Care &Research, EarlyView.
Objective We examined whether 18 months of strength training in individuals with knee varus alignment and medial tibiofemoral osteoarthritis (OA) reduced knee joint loads during walking compared to an attention control group. Methods This study was a secondary analysis of a randomized clinical trial that compared the effects of strength training to a ...
Stephen P. Messier, Matthew N. Vigliotti, Paige E. Rice, Brian Pietrosimone, Shannon L. Mihalko, Edward H. Ip, Richard F. Loeser, David J. Hunter, Ali Guermazi, Ryan Hill, Santiago Saldana, Kim L. Bennell, Paul DeVita   +12 more
wiley   +1 more source

Bis(2,2′-bipyridyl)-1κ2N,N′;3κ2N,N′-bis(4-bromo-2-formylphenolato)-1κ2O,O′;3κ2O,O′-bis[μ-2-(5-bromo-2-oxidobenzylideneamino)ethanesulfonato]-1:2κ3O:N,O2;2:3κ3N,O2:O-tricopper(II) monohydrate

Acta Crystallographica Section E, 2009
The title complex, [Cu3(C9H8BrNO4S)2(C7H4BrO2)2(C10H8N2)2]·H2O, lies on an inversion center located on the central Cu atom, which is four-coordinated in a square-planar geometry, whereas the outer Cu atoms related by symmetry are five ...
Ling Zhang
doaj   +1 more source