Results 61 to 70 of about 82,883 (302)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

From Fractal Geometry to Statistical Fractal

Recoletos Multidisciplinary Research Journal, 2013
The development from fractal geometry to fractal statistics was established in this paper. Interesting features such as self similarity, scale invariance, and the spacefilling property of objects (fractal dimension) of fractal geometry provided an ...
Roberto N. Padua, Mark S. Borres
doaj   +1 more source

Estimating impacts of emission specific characteristics on vehicle operation for quantifying air pollutant emissions and energy use

Journal of Traffic and Transportation Engineering (English ed. Online), 2017
This paper proposes and illustrates a methodology to predict the fraction of time motor vehicles spend in different operating conditions from readily observable variables called emission specific characteristics (ESC).
K.S. Nesamani, Jean-Daniel Saphores, Michael G. McNally, R. Jayakrishnan   +3 more
doaj   +1 more source

Instability of a Möbius Strip Minimal Surface and a Link with Systolic Geometry [PDF]

Physical Review Letters, 2015
We describe the first analytically tractable example of an instability of a nonorientable minimal surface under parametric variation of its boundary. A one-parameter family of incomplete Meeks Möbius surfaces is defined and shown to exhibit an instability threshold as the bounding curve is opened up from a double-covering of the circle.
Pesci, Adriana I., Goldstein, Raymond E., Alexander, Gareth P., Moffatt, H. Keith   +3 more
openaire   +3 more sources

Four dimensional hyperbolic link complements via Kirby calculus

, 2015
The primary aim of this thesis is to construct explicit examples of four dimensional hyperbolic link complements. Using the theory of Kirby diagrams and Kirby calculus we set up a general framework that one can use to attack such a problem.
Saratchandran, Hemanth
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Recovering the polyhedral geometry of fragmentsThe manuscript contains the link to the data

MethodsX
Not only is the geometry of rock fragments often well approximated by ideal convex polyhedra having few faces and vertices, but these numbers carry vital geophysical information on the fragmentation process.Despite their significance, the identification ...
János Török, Gábor Domokos
doaj   +1 more source

Study of kerf geometry of multilayers materials in abrasive water jet cutting process

MATEC Web of Conferences, 2017
The use of abrasive jet cutting in case of multilayers materials, shows particularities and difficulties, due to different hardness and thickness of layers.
Barabas Bogdan, Deaconescu Andrea
doaj   +1 more source