Results 51 to 60 of about 73,982 (262)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Estimating impacts of emission specific characteristics on vehicle operation for quantifying air pollutant emissions and energy use

Journal of Traffic and Transportation Engineering (English ed. Online), 2017
This paper proposes and illustrates a methodology to predict the fraction of time motor vehicles spend in different operating conditions from readily observable variables called emission specific characteristics (ESC).
K.S. Nesamani, Jean-Daniel Saphores, Michael G. McNally, R. Jayakrishnan   +3 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Recovering the polyhedral geometry of fragmentsThe manuscript contains the link to the data

MethodsX
Not only is the geometry of rock fragments often well approximated by ideal convex polyhedra having few faces and vertices, but these numbers carry vital geophysical information on the fragmentation process.Despite their significance, the identification ...
János Török, Gábor Domokos
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Ideal Hopf-link mode in phonon material Ba2OsH6

JPhys Materials
Phonon systems have emerged as potential platforms for exploring nontrivial band topologies. Meanwhile, two (or more) closed nodal lines (CNLs) may nest with each other and form a Hopf-link mode in momentum space.
Jianhua Wang, Weizhen Meng, Wenhong Wang, Zhenxiang Cheng, Shifeng Qian, Xiaotian Wang   +5 more
doaj   +1 more source

FR3 OFDM Multistatic ISAC Geometry-Aware Multi-Link Fusion and CRLB-Guided Design

IEEE Open Journal of the Communications Society
This paper presents a geometry-aware multi-link fusion framework for multistatic integrated sensing and communication (ISAC) in urban Frequency Range 3 (FR3) orthogonal frequency-division multiplexing (OFDM) channels, aligned with International Mobile ...
Shiv Shankar, Radha Krishna Ganti, J. Klutto Milleth   +2 more
doaj   +1 more source

cis-Dichloridobis(N,N,N′,N′-tetramethylethane-1,2-diamine)platinum(II)

Acta Crystallographica Section E, 2012
In the title complex, [PtCl2(C6H16N2)], the PtII atom adopts a distorted cis-PtN2Cl2 square-planar coordination geometry. The five-membered chelate ring adopts a twisted conformation.
Abdullah M. Asiri, Muhammad Nadeem Arshad, Muhammad Ishaq, Khalid A. Alamry, Tanveer Hussain Bokhari   +4 more
doaj   +1 more source

Instability of a Möbius Strip Minimal Surface and a Link with Systolic Geometry [PDF]

Physical Review Letters, 2015
We describe the first analytically tractable example of an instability of a nonorientable minimal surface under parametric variation of its boundary. A one-parameter family of incomplete Meeks Möbius surfaces is defined and shown to exhibit an instability threshold as the bounding curve is opened up from a double-covering of the circle.
Pesci, Adriana I., Goldstein, Raymond E., Alexander, Gareth P., Moffatt, H. Keith   +3 more
openaire   +3 more sources

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source