Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
THE ROLE OF PROJECTIVE GEOMETRY IN TALIAN EDUCATION AND INSTITUTIONS AT THE END OF THE 19TH CENTURY
Revista de História da Educação Matemática, 2023 At the end of the 19th century, projective geometry was at the basis of most geometric research in Italy, and of much other research work in Europe. Furthermore, through its close connection with descriptive geometry, it seemed particularly responsive to
Marta Menghini
doaj
Synaptic microenvironment and altered state of consciousness in schizophrenia: a possible link between synapse geometry and orchestrated objective reduction theory [PDF]
, 2023 Shahriar Ahmadpour
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Geometric pi Josephson junction: Current-phase relations and critical current
, 2009 Josephson junctions with an intrinsic phase shift of pi, so-called pi Josephson junctions, can be realized by a weak link of a d-wave superconductor with an appropriate boundary geometry.
Gumann, A., Iniotakis, C., Schopohl, N.
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Factorization in Phase-Space Finite Geometry and Weak Mutually Unbiased Bases
African Scientific Reports, 2023 A phase-space factorization of lines in finite geometry G(m) with variables in Zm and its correspondence in finite Hilbert space H(m) for m a non-prime was discussed. Using the method of Good [15], lines in G(m) were factorized as products of lines G(mi)
A. D. Adeshola +3 more
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Large N asymptotics of orthogonal polynomials, from integrability to algebraic geometry [PDF]
, 2005 In this short lecture, we compute asymptotics of orthogonal polynomials, from a saddle point approximation. This is an example of a calculation which shows the link between integrability, algebraic geometry and random matrices.Comment: Proceedings Les ...
Eynard, Bertrand
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Rolling Shutter Camera Relative Pose: Generalized Epipolar Geometry [PDF]
Computer Vision and Pattern Recognition, 2016 The vast majority of modern consumer-grade cameras employ a rolling shutter mechanism. In dynamic geometric computer vision applications such as visual SLAM, the so-called rolling shutter effect therefore needs to be properly taken into account.
Yuchao Dai, Hongdong Li, L. Kneip
semanticscholar +1 more source
Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
From Fractal Geometry to Statistical Fractal
Recoletos Multidisciplinary Research Journal, 2013 The development from fractal geometry to fractal statistics was established in this paper. Interesting features such as self similarity, scale invariance, and the spacefilling property of objects (fractal dimension) of fractal geometry provided an ...
Roberto N. Padua, Mark S. Borres
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