Results 71 to 80 of about 173,497 (273)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Transmission Error Prediction of RV Reducer based on SSA-BP
Jixie chuandong, 2022 There are many factors affecting the assembly quality of RV （Rotate Vector） reducer， and the assembly quality is unstable. In response to this situation， an optimized BP neural network quality prediction model based on the Sparrow Search Algorithm （SSA ...
Houzhen Sun, Hongbing Yuan, Bin Yu
doaj
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Link Quality Prediction for WSNs Based on Dynamic Bayesian Networks
工程科学与技术, 2017 :In wireless sensor networks,the link quality prediction is a basic issue in guarantying reliable data transmission and upper network protocol performance.In this paper,a link quality prediction mechanism based on dynamic Bayesian networks (DBN) was ...
SHU Jian +3 more
doaj
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Intelligent Systems with ApplicationsAccurate real-time prediction of link quality is crucial for enhancing the reliable responsiveness of wearable devices within Wireless Wearable Sensor Networks (WWSNs).
Minghu Zha +4 more
doaj +1 more source
A link prediction approach to cancer drug sensitivity prediction
, 2017 Background: Predicting the response to a drug for cancer disease patients based on genomic information is an important problem in modern clinical oncology.
Turki, Turki +3 more
core +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source