Results 111 to 120 of about 1,267 (272)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Adding Controllable Linkability to Pairing-Based Group Signatures For Free [PDF]

, 2016
Group signatures, which allow users of a group to anonymously produce signatures on behalf of the group, are an important cryptographic primitive for privacy-enhancing applications.
Raphael Spreitzer, Thomas Unterluggauer, Daniel Slamanig   +2 more
core   +1 more source

Symbolic privacy analysis through linkability and detectability

, 2013
More and more personal information is exchanged on-line using communication protocols. This makes it increasingly important that such protocols satisfy privacy by data minimisation. Formal methods have been used to verify privacy properties of protocols;
Weger, de, B.M.M., Zannone, N., Agudo, I., Martinelli, F., Pearson, S., Fernández-Gago, C., Veeningen, M.G.   +6 more
core   +2 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

de-Linkability: a Privacy-Preserving Constraint for Safely Outsourcing Multimedia Documents

, 2013
International audienceOutsourcing social multimedia documents is a growing practice among several companies in a way to shift their business globally. It is a cost-effective process where those companies tend to gain more profits disregarding eventual ...
Elia, Charbel, Raad, Eliana J., Haraty, Ramzi, Chbeir, Richard, Al Bouna, Bechara   +4 more
core   +3 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

ARS-Chain: A Blockchain-Based Anonymous Reputation-Sharing Framework for E-Commerce Platforms

Mathematics
E-commerce platforms incorporate reputation systems that allow buyers to rate sellers after transactions. However, existing reputation systems face challenges such as privacy leakage, linkability, and multiple rating attacks.
Yungui Chen, Li Feng, Qinglin Zhao, Liwei Tian, Lei Yang   +4 more
doaj   +1 more source