Results 91 to 100 of about 1,267 (272)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Linkable group signatures against malicious regulators for regulated privacy-preserving cryptocurrencies

High-Confidence Computing
With the emergence of illegal behaviors such as money laundering and extortion, the regulation of privacy-preserving cryptocurrency has become increasingly important.
Xiao Wang, Yanqi Zhao, Lingyue Zhang, Min Xie, Yong Yu, Huilin Li   +5 more
doaj   +1 more source

A linkable identity privacy algorithm for HealthGrid.

Studies in health technology and informatics, 2005
The issues of confidentiality and privacy have become increasingly important as Grid technology is being adopted in public sectors such as healthcare. This paper discusses the importance of protecting the confidentiality and privacy of patient health/medical records, and the challenges exhibited in enforcing this protection in a Grid environment.
Zhang, N, Rector, A, Buchan, I, Shi, Q, Kalra, D, Rogers, J, Goble, C, Walker, S, Ingram, D, Singleton, P   +9 more
openaire   +4 more sources

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Anonymous Stateless Communication Architecture: Design, Network Performance Analysis, and Integration of Tor Hidden Services for Privileged Communications

Journal of Telecommunications and Information Technology
This paper presents the network architecture and empirical performance analysis of the Proof of Concept (POC) for a stateless Tor-based communication system designed for privileged communication.
Tomasz Janczewski
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

An Efficient and Certificateless Conditional Privacy-Preserving Authentication Scheme for Wireless Body Area Networks Big Data Services

IEEE Access, 2018
To gurantee the security and privacy of the patient's physiological data in wirelss body area networks (WBANs), it is important to secure the communication between the personal digital assistance held by the WBANs client and the application provider ...
Sai Ji, Ziyuan Gui, Tianqi Zhou, Hongyang Yan, Jian Shen   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Template-Driven Multimodal Face Pseudonymization for Privacy-Preserving Big Data Analytics

Algorithms
Profile images from social networks are a valuable source of data for AI analytics, but they contain biometric identifiers that pose serious privacy risks.
Yeong Su Lee, Hendrik Bothe, Michaela Geierhos   +2 more
doaj   +1 more source