Results 171 to 180 of about 22,826,976 (294)

A Robust Linkage Analysis Method Using Combined Allele Sharing and Transmission Disequilibrium Information from Case-Parent Tetrad Families

, 2012
[[abstract]]There are two types of linkage information, the allele sharing information and transmission disequilibrium information, that can be extracted from case-parent tetrad families for deriving statistics for test of linkage.
王俊毅;Jiun-Yi Wang;C.-D. Hou; J. J. Tai
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

QTL mapping, validation, and candidate gene predicting for maize plant architecture traits via bulked segregant analysis plus linkage analysis with F₂ population. [PDF]

BMC Plant Biol
Wang S, Wang Y, Li X, Ge B, Su C.
europepmc   +1 more source

Healthcare costs of a telemonitoring programme for heart failure: indirect deterministic data linkage analysis. [PDF]

ESC Heart Fail, 2022
Pathak A, Levy P, Roubille F, Chatellier G, Mercier G, Alami S, Lancman G, Pasche H, Laurelli C, Delval C, Ramirez-Gil JF, Galinier M.   +11 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Digital PCR linkage analysis resolves <i>Streptococcus pneumoniae</i> signature from commensal interference in saliva samples: identifying wolves among sheep in wolf's clothing. [PDF]

Microbiol Spectr
Miellet WR, Nieuwenhuijsen T, van den Oetelaar EHMR, van Veldhuizen J, Rots NY, Trzciński K, Mariman R.   +6 more
europepmc   +1 more source

Identification of carrier status of Xp22.31 microdeletions associated with X-linked ichthyosis at the single-cell level using haplotype linkage analysis by karyomapping. [PDF]

J Assist Reprod Genet, 2023
Yang J, Shi H, Niu W, Bao X, Liu H, Chen C, Jin H, Song W, Sun Y.   +8 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The Rate of Procedures Required to Maintain Hemodialysis Vascular Access: A Data Linkage Analysis. [PDF]

Kidney360
Richards KG, Polkinghorne KR, Polkinghorne KR, McGregor DO, Walker RC, Walker C, Williman JA, Green SC.   +7 more
europepmc   +1 more source

Noninvasive fetal genotyping of single nucleotide variants and linkage analysis for prenatal diagnosis of monogenic disorders. [PDF]

Hum Genomics, 2022
Wu W, Zhou X, Jiang Z, Zhang D, Yu F, Zhang L, Wang X, Chen S, Xu C.   +8 more
europepmc   +1 more source