Results 191 to 200 of about 22,826,976 (294)

Genetic dissection of hundred-kernel weight through combined genome-wide association study and linkage analysis in tropical maize. [PDF]

BMC Genomics
Shi M, Jiang F, Shaw RK, Ijaz B, Sun J, Fan X.   +5 more
europepmc   +1 more source

Suboptimal oral health and the risk of cardiovascular disease in the presence of competing death: a data linkage analysis. [PDF]

Can J Public Health, 2023
Aldossri M, Saarela O, Rosella L, Quiñonez C.   +3 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Genome-wide association and linkage analysis of histidine-rich glycoprotein identifies common variants associated with plasma histidine-rich glycoprotein concentrations. [PDF]

Res Pract Thromb Haemost
Underwood MI, Ozel AB, Deepak T, McGee B, Siemieniak D, Malik RA, Teney C, Kretz CA, Weitz J, Desch KC.   +9 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Three-dimensional linkage analysis with digital PCR for genome integrity and identity of recombinant adeno-associated virus. [PDF]

Sci Rep
Duong T, Firmo M, Li CT, Gu B, Wang P.
europepmc   +1 more source

Linkage analysis identifies novel genetic modifiers of microbiome traits in families with inflammatory bowel disease. [PDF]

Gut Microbes, 2022
Sharma A, Szymczak S, Rühlemann M, Freitag-Wolf S, Knecht C, Enderle J, Schreiber S, Franke A, Lieb W, Krawczak M, Dempfle A.   +10 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Characterization of Unfractionated Polysaccharides in Brown Seaweed by Methylation-GC-MS-Based Linkage Analysis. [PDF]

Mar Drugs
Bajwa B, Xing X, Serin SC, Hayes M, Terry SA, Gruninger RJ, Abbott DW.   +6 more
europepmc   +1 more source

Long-read sequencing on the SMRT platform enables efficient haplotype linkage analysis in preimplantation genetic testing for β-thalassemia. [PDF]

J Assist Reprod Genet, 2022
Wu H, Chen D, Zhao Q, Shen X, Liao Y, Li P, Chiu PCN, Zhou C.   +7 more
europepmc   +1 more source