Results 61 to 70 of about 22,826,976 (294)
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa +7 more
wiley +1 more source
Meta‐analysis of linkage studies [PDF]
Genetic Epidemiology, 1999 AbstractLander and Kruglyak [1995] gave guidelines for interpreting linkage results based on estimating how often a particular threshold for significance would be exceeded by chance in a single genome scan. What is unknown is how often two or more genome scans would exceed a particular threshold within the same region.
J A, Badner, L R, Goldin
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
On a Randomization Procedure in Linkage Analysis [PDF]
The American Journal of Human Genetics, 1999 Although much theoretical work has been undertaken to derive thresholds for statistical significance in genetic linkage studies, real data are often complicated by many factors, such as missing individuals or uninformative markers, which make the validity of these theoretical results questionable. Many simulation-based methods have been proposed in the
Zhao, Hongyu +2 more
openaire +2 more sources
Linkage to chromosome 11p12 in two Maltese families with a highly penetrant form of osteoporosis [PDF]
, 2007 Osteoporosis is a metabolic bone disease with a strong genetic component. Family-based linkage studies were performed by a number of investigators to try to identify loci that might contain genes responsible for an increased susceptibility to ...
Brincat, Mark P. +7 more
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Dynamic behaviour of a vibratory linkage mechanism with bearing clearance. [PDF]
, 1974 PhDThe work presented involves the theoretical and experimental studies of the kinematic and dynamic effects of bearing clearance in linkage mechanisms.
Wu, C
core +4 more sources
Exclusion of the Locus for Autosomal Recessive Pseudohypoaldosteronism Type 1 from the Mineralocorticoid Receptor Gene Region on Human Chromosome 4q by Linkage Analysis. [PDF]
, 1995 Pseudohypoaldosteronism type 1 (PHA1) is an uncommon inherited disorder characterized by salt-wasting in infancy arising from target organ unresponsiveness to mineralocorticoids.
Hanukoglu, A. +10 more
core +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Regression analysis under probabilistic multi-linkage
, 2011 Linkage errors can occur when probability-based methods are used to link records from two distinct data sets corresponding to the same target population.
Gunky Kim (20124087) +1 more
core +1 more source