Results 91 to 100 of about 193,370 (286)

Genetic prediction of blood cell reactivity and its potential causal influence on bone continuity and density disorders

Animal Models and Experimental Medicine, EarlyView.
We applied Mendelian randomization to explore causal links between blood cell traits and skeletal disorders. Using genetic instruments from large‐scale summary statistics, we assessed effects on bone continuity, density, and structural integrity. Sensitivity and reverse analyses confirmed robust associations, highlighting potential shared biological ...
Zhiqin Deng, Zhe Zhao, Wenting Jiang, Xiaoqiang Chen, Jianquan Liu, Xu Tao, Zhengyang Lin, Zhenhan Deng, Wencui Li   +8 more
wiley   +1 more source

Models and partition of variance for quantitative trait loci with epistasis and linkage disequilibrium

BMC Genetics, 2006
Background A genetic model about quantitative trait loci (QTL) provides a basis to interpret the genetic basis of quantitative traits in a study population, such as additive, dominance and epistatic effects of QTL and the partition of genetic variance ...
Wang Tao, Zeng Zhao-Bang
doaj   +1 more source

Error threshold in finite populations

, 1998
A simple analytical framework to study the molecular quasispecies evolution of finite populations is proposed, in which the population is assumed to be a random combination of the constiyuent molecules in each generation,i.e., linkage disequilibrium at ...
A. Prügel-Bennett, D. Alves, D. Alves, D. Alves, D. E. Goldberg, D. Gillespie, D. Gillespie, E. van Nimwegen, G. Woodcock, H. Inagaki, I. Leuthäusser, I. Leuthäusser, J. F. Fontanari, J. Maynard Smith, J. S. McCaskill, J. Swetina, M. Eigen, M. Eigen, M. Nowak, M. W. Feldman, P. G. Higgs, P. Tarazona, S. Galluccio, S. Galluccio, T. Wiehe, W. Ebeling, W. Gabriel, Y-C. Zhang   +27 more
core   +1 more source

Mapping adaptation of barley to droughted environments [PDF]

, 2008
Identifying barley genomic regions influencing the response of yield and its components to water deficits will aid in our understanding of the genetics of drought tolerance and the development of more drought tolerant cultivars. We assembled a population
Akar, T., Al-Yassin, A., Araus, J.L., Baum, M., Benbelkacem, A., Bort, J., Ceccarelli, S., Choumane, W., Comadran, J., Dahan, R., Eeuwijk, F.A., van, Grando, S., Hackett, C.A., Mastrangelo, A.M., Ouabbou, H., Pecchioni, N., Pswarayi, A., Romagosa, I., Russell, J.R., Stanca, A.M., Thomas, W.T.B.   +20 more
core   +3 more sources

Genetic Diversity, Adaptation, Wild Introgression, and Coat Color Mutation of Golden Yak

Animal Research and One Health, EarlyView.
Genetic diversity, adaptation, wild introgression, and coat color mutation of golden yak from two populations on the Qinghai‐Xizang Plateau. ABSTRACT The golden yak lives on the Qinghai‐Xizang Plateau with a golden coat and adapts to high altitudes and strong ultraviolet environment. The golden coat is a prominent phenotype in many domesticated species,
Huixuan Yan, Jialei Chen, Chuzhao Lei, Fengwei Zhang, Shunzhong He, Weiru Song, Hongyan Ma, Shuling Li, Guomei Li, Laba Yongcuo, Jianlin Han, Johannes A. Lenstra, Qiang Zhang, Rende Song, Basang Wangdui, Ningbo Chen   +15 more
wiley   +1 more source

Quantitative genetics theory for non-inbred populations in linkage disequilibrium

Genetics and Molecular Biology, 2004
Although linkage disequilibrium, epistasis and inbreeding are common phenomena in genetic systems that control quantitative traits, theory development and analysis are very complex, especially when they are considered together.
José Marcelo Soriano Viana
doaj   +1 more source

Genomic Structural Variations Provide Insights Into Litter Size and Teat Number Traits in Hu Sheep

Animal Research and One Health, EarlyView.
Here, we conducted whole genome sequencing on 300 Hu sheep with an average depth of 16.51X. Two candidate genes associated with litter size and teat number traits were identified, namely MAST2 and AFDN. ABSTRACT Litter size and the teat number are important economic indicators in sheep production.
Xin Xiang, Wei Dai, Jiqiang Liu, Zhengguang Wang   +3 more
wiley   +1 more source

Effects of the Ordering of Natural Selection and Population Regulation Mechanisms on Wright-Fisher Models

G3: Genes, Genomes, Genetics, 2017
We explore the effect of different mechanisms of natural selection on the evolution of populations for one- and two-locus systems. We compare the effect of viability and fecundity selection in the context of the Wright-Fisher model with selection under ...
Zhangyi He, Mark Beaumont, Feng Yu
doaj   +1 more source

Linkage Disequilibrium-Based Inference of Genome Homology and Chromosomal Rearrangements Between Species

G3: Genes, Genomes, Genetics, 2020
The aim of this study was to analyze the genomic homology between cattle (Bos taurus) and buffaloes (Bubalus bubalis) and to propose a rearrangement of the buffalo genome through linkage disequilibrium analyses of buffalo SNP markers referenced in the ...
Daniel Jordan de Abreu Santos, Gregório Miguel Ferreira de Camargo, Diercles Francisco Cardoso, Marcos Eli Buzanskas, Rusbel Raul Aspilcueta-Borquis, Naudin Alejandro Hurtado-Lugo, Francisco Ribeiro de Araújo Neto, Lúcia Galvão de Albuquerque, Li Ma, Humberto Tonhati   +9 more
doaj   +1 more source

Polymorphism of the tumor necrosis factor beta gene in systemic lupus erythematosus [PDF]

, 1993
We investigated the Nco I restriction fragment length polymorphism (RFLP) of the tumor necrosis factor beta (TNFB) gene in 173 patients with systemic lupus erythematosus (SLE), 192 unrelated healthy controls, and eleven panel families, all of German ...
Albert, E. D., Bettinotti, M. P., Deicher, H., Hartung, K., Keller, E., Messer, Gerald, Weiss, Elisabeth H.   +6 more
core   +1 more source