Results 71 to 80 of about 128,239 (292)
Advanced Science, EarlyView.Lipoic acid synthase (lias) can regulate α‐KG levels through lipoylation, thereby negatively regulating HIF‐1α protein levels via PHD under hypoixa. The Hap2 allele of lias exhibits lower expression levels than Hap1, leading to the accumulation of more HIF‐1α protein and thereby enhancing hypoxia tolerance. ABSTRACT Hypoxia stress seriously affects the
Jie Ding +7 more
wiley +1 more source
G3: Genes, Genomes, Genetics, 2017 The aquatic planorbid snail Biomphalaria glabrata is one of the most intensively-studied mollusks due to its role in the transmission of schistosomiasis. Its 916 Mb genome has recently been sequenced and annotated, but it remains poorly assembled.
Jacob A. Tennessen +2 more
doaj +1 more source
Testing Linkage Disequilibrium in Sibships [PDF]
The American Journal of Human Genetics, 2000 We describe the use of multivariate regression for testing allelic association in the presence of linkage, using marker genotype data from sibships. The test is valid, provided that the correct mean structure is modeled but does not require the correlation structure within families to be specified. The test can be implemented using standard statistical
Siegmund, Kimberly D. +3 more
openaire +2 more sources
Haplotype analysis and linkage disequilibrium for DGAT1 [PDF]
, 2010 This study focused on haplotype effects and linkage disequilibrium (LD) for the K232A locus and the promoter VNTR in the DGAT1 gene. Analyses were carried out in three German Holstein Frisian populations (including 492, 305, and 518 animals) for milk ...
Strucken, Eva M. +3 more
core
Linkage disequilibrium diagram among five GLP-1R SNPs. [PDF]
, 2023 (A) Linkage disequilibrium D’ value between SNPs. The higher the value, the darker the color of the block, the stronger the correlation of the linkage disequilibrium. (B) Linkage disequilibrium r2 value between SNPs.
Yawei Tian (5607704) +5 more
core +1 more source
Advanced Science, EarlyView.As a pilot phase of the Central Asian Genomic Diversity Project, whole‐genome sequencing of 166 individuals from 20 Central Asian and Afghan Hazara populations reveals fine‐scale substructure shaped by repeated trans‐Eurasian migration and admixture. Integrated analyses uncover post‐admixture adaptation, archaic introgression, and medically relevant ...
Mengge Wang +11 more
wiley +1 more source
Relationship between NAFLD and coronary artery disease: A Mendelian randomization study
Hepatology, EarlyView., 2022 Abstract Background and Aims There is an ongoing debate on whether NAFLD is an active contributor or an innocent bystander in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to assess the causal relationship between NAFLD and CAD.
Zhewen Ren +4 more
wiley +1 more source
A Robust Linkage Analysis Method Using Combined Allele Sharing and Transmission Disequilibrium Information from Case-Parent Tetrad Families [PDF]
, 2012 [[abstract]]There are two types of linkage information, the allele sharing information and transmission disequilibrium information, that can be extracted from case-parent tetrad families for deriving statistics for test of linkage.
王俊毅;Jiun-Yi Wang;C.-D. Hou; J. J. Tai
core
Linkage disequilibrium Nile tilapia [PDF]
, 2019 Dataset for linkage disequilibrium in Nile tilapia farmed ...
José Manuel Yáñez (6201729) +1 more
core +1 more source
Advanced Science, EarlyView.Large‐scale UK Biobank analyses identify clinical and proteomic signatures for early prediction of valvular heart disease and its subtypes. Proteins add predictive value for VHD, AVS, and MVR, with outcome‐specific compact panels showing translational potential. Multi‐layer evidence highlights matrix remodeling, protease regulation, immune inflammation,
Zhihao Jiang +10 more
wiley +1 more source