Results 51 to 60 of about 387,849 (295)

Tapasin gene polymorphism in systemic onset juvenile rheumatoid arthritis: a family-based case-control study [PDF]

, 2005
Juvenile rheumatoid arthritis (JRA) comprises a group of chronic systemic inflammatory disorders that primarily affect joints and can cause long-term disability.
Woo, P, Colbert, RA, Bukulmez, H, Thompson, SD, Twine, NA, Tsoras, M, Glass, DN, Olson, JM, Fife, M, Elston, RC   +9 more
core  

Linkage score disequilibrium analysis results.

, 2023
Linkage score disequilibrium metrics for the three GWAS of the photoreceptor layers following analysis using LDSCore [20]. Metrics include lambda genomic control (GC), linkage disequilibrium score (LDSC) intercept and LDSC ratio. (PDF)
Ewan Birney (7728), Andrew R. Webster (8221650), Omar A. Mahroo (13844402), Tomas W. Fitzgerald (10789662), Praveen J. Patel (8027564), Anthony P. Khawaja (8770904), Hannah Currant (10789659)   +6 more
core   +1 more source

Large‐scale Whole‐Exome Sequencing Defines the Protein‐Coding Architecture of Retinal Structure, Visual Function, and Major Blinding Diseases

Advanced Science, EarlyView.
Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li, Yijun Ge, Jingxiao Du, Liu Yang, Bangsheng Wu, Chenyue Hang, Mengxi Shen, Yimin Mao, Ting Zhang, Qiyu Bo, Tianyuan Zhao, Yutian Jiao, Yazhi Wang, Shunxiang Gao, Jieqiong Chen, Junran Sun, Tong Li, Huixun Jia, Yang Dou, Wei Cheng, Xiaoling Wan, Jintai Yu, Xiaodong Sun, Bai Lu   +23 more
wiley   +1 more source

An Artificially Selected Cytokinin‐Pathway Transcription Factor Balances Soybean Yield and Pathogen Resistance

Advanced Science, EarlyView.
A cytokinin pathway transcription factor, RR2b, was artificially selected during soybean domestication and improvement based on its differential transcriptional activity, which correlates with ATT repeat polymorphisms in its promoter. RR2b balances yield and defense by fine‐tuning its expression level and offers a promising target for decoupling trade ...
Qun Ma, Yaqing Chen, Yiwen Gao, Xueting Hu, Qun Yang, Yucheng Liu, Peiyong Xin, Jijun Yan, Jinfang Chu, Lei Li, Zhixi Tian, Bo Ren   +11 more
wiley   +1 more source

Whole Genome Linkage Disequilibrium and Effective Population Size in a Coho Salmon (Oncorhynchus kisutch) Breeding Population Using a High-Density SNP Array

Frontiers in Genetics, 2019
The estimation of linkage disequilibrium between molecular markers within a population is critical when establishing the minimum number of markers required for association studies, genomic selection, and inferring historical events influencing different ...
Agustín Barría, Kris A. Christensen, Grazyella Yoshida, Ana Jedlicki, Jong S. Leong, Eric B. Rondeau, Jean P. Lhorente, Ben F. Koop, William S. Davidson, José M. Yáñez, José M. Yáñez   +10 more
doaj   +1 more source

A population genetics model of marker-assisted selection [PDF]

, 1997
A deterministic two-loci model was developed to predict genetic response to marker-assisted selection (MAS) in one generation and in multiple generations.
Luo, Z. W., Woolliams, J. A., Luo, Z.W., Woolliams, John, Thompson, R.   +4 more
core  

Transposable Element–Driven PIEZO Mutation Enhances Locust Flight in Plateau Hypoxia

Advanced Science, EarlyView.
Why transposable elements (TEs) persisted or expanded in genomes remains a mystery. Using integrated analysis of TE macro‐ and microevolution in locusts, our results showed that thousands of TE insertions promoted widespread adaptive variation. Subfamilies of candidate adaptive TEs amplified and reshaped species‐level genomic architecture.
Xuanzhao Li, Ying Liu, Longsheng Xing, Xianliang Huang, Yingming Sun, Lei Yue, Yuze Zhang, Huilong Du, Bing Chen   +8 more
wiley   +1 more source

Association mapping for kernel phytosterol content in almond

Frontiers in Plant Science, 2015
Almond kernels are a rich source of phytosterols, which are important compounds for human nutrition. The genetic control of phytosterol content has not yet been documented in almond.
Carolina eFont i Forcada, Leonardo eVelasco, Rafel eSocias i Company, Angel eFernández i Martí   +3 more
doaj   +1 more source

Haplotype analysis and linkage disequilibrium for DGAT1 [PDF]

, 2010
This study focused on haplotype effects and linkage disequilibrium (LD) for the K232A locus and the promoter VNTR in the DGAT1 gene. Analyses were carried out in three German Holstein Frisian populations (including 492, 305, and 518 animals) for milk ...
Strucken, Eva M., De Koning, Dirk-Jan, Rahmatalla, Siham, Brockmann, Gudrun A.   +3 more
core  

A web application to perform linkage disequilibrium and linkage analyses on a computational grid

, 2009
Motivation: Unravelling the genetic architecture of complex traits requires large amounts of data, sophisticated models and large computational resources.
Hernandez Sanchez, Julio, Knott, S, Grunchec, J-A   +2 more
core   +1 more source