Results 51 to 60 of about 193,370 (286)

Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk

Advanced Science, EarlyView.
Integration of a pancreatic eQTL map with a GWAS meta‐analysis identifies 82 putative functional variants and 15 genes. The association between rs11102484 and pancreatic cancer risk is observed in a total of 5699 cases and 8467 controls. The G allele of rs11102484 weakens ZNF263 binding and the silencer‐promoter interaction, thereby increasing ST7L ...
Xiaoyang Wang, Hui Geng, Zhengyan Yao, Yuan Jiang, Can Chen, Zequn Lu, Shuangshuang Tian, Ming Zhang, Ruiyan Liu, Chenxi Feng, Bin Li, Xiaoping Miao, Jianbo Tian, Shaokai Zhang, Ying Zhu   +14 more
wiley   +1 more source

Whole Genome Linkage Disequilibrium and Effective Population Size in a Coho Salmon (Oncorhynchus kisutch) Breeding Population Using a High-Density SNP Array

Frontiers in Genetics, 2019
The estimation of linkage disequilibrium between molecular markers within a population is critical when establishing the minimum number of markers required for association studies, genomic selection, and inferring historical events influencing different ...
Agustín Barría, Kris A. Christensen, Grazyella Yoshida, Ana Jedlicki, Jong S. Leong, Eric B. Rondeau, Jean P. Lhorente, Ben F. Koop, William S. Davidson, José M. Yáñez, José M. Yáñez   +10 more
doaj   +1 more source

Transmission/disequilibrium tests incorporating unaffected offspring. [PDF]

PLoS ONE, 2014
We propose a new method for family-based tests of association and linkage called transmission/disequilibrium tests incorporating unaffected offspring (TDTU).
Qinyu Wei, Yuanli Chen, Zheng Zeng, Chang Shu, Lu Long, Jianhua Lu, Yangxin Huang, Ping Yin   +7 more
doaj   +1 more source

Genetic Control of Tissue Remodeling by a Non‐Coding SNP in ITGA8 Explains Carotenoid‐Based Color Polymorphism in Marine Mollusks

Advanced Science, EarlyView.
In this study, the orange‐muscle giant abalone (Haliotis gigantea) is used as a model to identify a non‐coding SNP that disrupts the interaction between ITGA8 pre‐mRNA and the splicing factor ILF2, leading to altered ITGA8 splicing. These splicing changes promote carotenoid accumulation in abalone muscle through the regulation of tissue remodeling ...
Xiaohui Wei, Wenzhu Peng, Zekun Huang, Bingye Yang, Yiyu Wu, Minzhen Han, Yi Wang, Bingling Peng, Guosheng Hu, Jiawei Hong, Guijia Liu, Linwei Nie, Yang Gan, Miaoqin Huang, Xuan Luo, Weiwei You, Wen Liu, Caihuan Ke   +17 more
wiley   +1 more source

JLIN: A java based linkage disequilibrium plotter

BMC Bioinformatics, 2006
Background A great deal of effort and expense are being expended internationally in attempts to detect genetic polymorphisms contributing to susceptibility to complex human disease. Techniques such as Linkage Disequilibrium mapping are being increasingly
McCaskie Pamela A, Carter Kim W, Palmer Lyle J   +2 more
doaj   +1 more source

Interleukin-1 polymorphisms associated with increased risk of gastric cancer [PDF]

, 2000
Helicobacter pylori infection is associated with a variety of clinical outcomes including gastric cancer and duodenal ulcer disease. The reasons for this variation are not clear, but the gastric physiological response is influenced by the severity and ...
A Cox, B Ruiz, CA Dinarello, Charles S. Rabkin, Chiu-Chin Yuan, Correa, P., CR Yu, D Basso, DM Parkin, E El-Omar, E El-Omar, EJ Kuipers, EM El-Omar, Emad M. El-Omar, F Pociot, George Lanyon, HC Jung, Howard A. Young, HW Chow, IL Beales, Jay H. Bream, Jesus Herrera, JL Wallace, Jolanta Lissowska, Joseph F. Fraumeni, Kenneth E. L. McColl, LA Noach, LE Hansson, M Carrington, Mary Carrington, Maureen Martin, MJ Blaser, MM Wolfe, NA Tountas, Nathaniel Rothman, P Sipponen, RM Royall, RW Stockbruegger, S Santtila, T Andus, VA Danis, Wong-Ho Chow, Y Yamaoka   +42 more
core   +2 more sources

Natural Variation of NAR5 Determines Nitrogenase Activity and the Yield in Soybean

Advanced Science, EarlyView.
This study identified NAR5, a gene encoding a subtilisin‐like protease, that regulates nitrogenase activity in soybean nodules. Overexpressing NAR5 delayed nodule senescence, enhancing nitrogenase activity, yield, and low‐nitrogen tolerance. The elite haplotype NAR5HapI‐1 linked to superior nitrogenase activity and greater seed weight has been ...
Chao Ma, Hanyu Zhao, Haojie Feng, Xulun Dong, Lin Chen, Mingliang Yang, Runyi Chen, Chengjun Lei, Chunyan Liu, Qingshan Chen, Dawei Xin, Jinhui Wang   +11 more
wiley   +1 more source

Effects of the number of markers per haplotype and clustering of haplotypes on the accuracy of QTL mapping and prediction of genomic breeding values [PDF]

, 2009
The aim of this paper was to compare the effect of haplotype definition on the precision of QTL-mapping and on the accuracy of predicted genomic breeding values.
Mario PL Calus, Theo HE Meuwissen, Jack J Windig, Egbert F Knol, Chris Schrooten, Addie LJ Vereijken, Roel F Veerkamp, THE Meuwissen, THE Meuwissen, MPL Calus, L Grapes, L Grapes, K Yu, HG deVries, D Habier, WM Muir, TR Solberg, M Lynch, T Druet, B Hayes, DS Falconer, A Legarra, RL Fernando, THE Meuwissen, WG Hill, BJ Hayes, EJ Pollak, L Ronnegard, E Uleberg   +28 more
core   +3 more sources

Deciphering the Evolution Pattern of Structural Variations Overlapped With Repetitive Sequence During Cattle Evolution

Advanced Science, EarlyView.
The authors complement bovine pan‐SV with massive novel structural variations (SVs) identified through long‐read sequencing of 83 globally distributed cattle breeds. Repetitive sequence‐mediated SVs (rep‐SV) exhibit distinct dynamic patterns throughout cattle sub‐speciation and/or domestication processes, including uneven distribution between chr‐X and
Zhifan Guo, Jinxiu Li, Adeniyi C. Adeola, Xueyan Jiang, Juntao Ma, Jian Xiao, Dexiang Hu, Kaixing Qu, Haihong Wu, Junren Chen, Zhanxing He, Tingting Yin, Ali Esmailizadeh, Jing Luo, Olivier Hanotte, Ya‐Ping Zhang, Yan Li   +16 more
wiley   +1 more source

Association mapping for kernel phytosterol content in almond

Frontiers in Plant Science, 2015
Almond kernels are a rich source of phytosterols, which are important compounds for human nutrition. The genetic control of phytosterol content has not yet been documented in almond.
Carolina eFont i Forcada, Leonardo eVelasco, Rafel eSocias i Company, Angel eFernández i Martí   +3 more
doaj   +1 more source