Results 81 to 90 of about 193,370 (286)
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT Major depression and suicide are critical public health concerns, particularly in underrepresented populations with unique genetic and sociocultural contexts. The Maya‐mestizo population presents the highest suicide rates in the country but remains understudied in psychiatric genetics. This study evaluated the association between three genetic
Marta Menjivar +3 more
wiley +1 more source
, 2010 The mapping between genotype and phenotype is encoded in the complex web of epistatic interaction between genetic loci. In this rugged fitness landscape, recombination processes, which tend to increase variation in the population, compete with selection ...
A. Hartmann +18 more
core +1 more source
Testing Linkage Disequilibrium in Sibships [PDF]
The American Journal of Human Genetics, 2000 We describe the use of multivariate regression for testing allelic association in the presence of linkage, using marker genotype data from sibships. The test is valid, provided that the correct mean structure is modeled but does not require the correlation structure within families to be specified. The test can be implemented using standard statistical
Siegmund, Kimberly D. +3 more
openaire +2 more sources
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT In epidemiological studies, obsessive‐compulsive disorder (OCD) is robustly associated with increased risk of cardiometabolic disorders, including cardiovascular diseases, type 2 diabetes, and obesity. However, the mechanisms behind these associations are unclear. We conducted genetic correlation analyses to explore shared genetic etiology and
Robyn E. Wootton +217 more
wiley +1 more source
Inferring linkage disequilibrium from non-random samples†
BMC Genomics, 2010 Background Linkage disequilibrium (LD) plays a fundamental role in population genetics and in the current surge of studies to screen for subtle genetic variants affecting complex traits.
Hu Xiaohua +5 more
doaj +1 more source
Long-range linkage disequilibrium in French beef cattle breeds
Genetics Selection Evolution, 2021 Background Linkage disequilibrium (LD) is a key parameter to study the history of populations and to identify and fine map quantitative trait loci (QTL) and it has been studied for many years in animal populations.
Abdelmajid El Hou +4 more
doaj +1 more source
Linkage Disequilibrium in Domestic Sheep [PDF]
Genetics, 2002 Abstract The last decade has seen a dramatic increase in the number of livestock QTL mapping studies. The next challenge awaiting livestock geneticists is to determine the actual genes responsible for variation of economically important traits.
McRae, AF +5 more
openaire +2 more sources
Animal Models and Experimental Medicine, EarlyView.This study presents an integrative multi‐omics framework to uncover the molecular mechanisms and potential biomarkers of chronic thromboembolic pulmonary hypertension (CTEPH). Anthropometric and biochemical data were correlated using canonical correlation analysis, revealing key cardiometabolic associations. Single‐cell RNA sequencing identified immune
Xiaopeng Liu +4 more
wiley +1 more source
BMC Genomics, 2009 Background It is well known that the pattern of linkage disequilibrium varies between human populations, with remarkable geographical stratification.
Navarro Arcadi +12 more
doaj +1 more source
BMC Evolutionary Biology, 2020 Background Many species are threatened with extinction as their population sizes decrease with changing environments or face novel pathogenic threats.
Christelle Vangenot +6 more
doaj +1 more source