Results 81 to 90 of about 128,239 (292)

Genotype determination for polymorphisms in linkage disequilibrium

BMC Bioinformatics, 2009
Background Genome-wide association studies with single nucleotide polymorphisms (SNPs) show great promise to identify genetic determinants of complex human traits.
Anton-Culver Hoda, Ziogas Argyrios, Garner Chad, Yu Zhaoxia, Schaid Daniel J   +4 more
doaj   +1 more source

The effect of initial linkage disequilibrium and natural selection in pooled populations : experiments with Tribolium and simulation [PDF]

, 1972
In chapter 2 a number of the mechanisms are discussed through which genetic polymorphisms can be maintained in natural populations: overdominance, frequency dependent selection and neutral alleles with associative overdominance.
Stam, P.
core  

Large‐scale Whole‐Exome Sequencing Defines the Protein‐Coding Architecture of Retinal Structure, Visual Function, and Major Blinding Diseases

Advanced Science, EarlyView.
Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li, Yijun Ge, Jingxiao Du, Liu Yang, Bangsheng Wu, Chenyue Hang, Mengxi Shen, Yimin Mao, Ting Zhang, Qiyu Bo, Tianyuan Zhao, Yutian Jiao, Yazhi Wang, Shunxiang Gao, Jieqiong Chen, Junran Sun, Tong Li, Huixun Jia, Yang Dou, Wei Cheng, Xiaoling Wan, Jintai Yu, Xiaodong Sun, Bai Lu   +23 more
wiley   +1 more source

Genome-wide analysis of zygotic linkage disequilibrium and its components in crossbred cattle

BMC Genetics, 2012
Background Linkage disequilibrium (LD) between genes at linked or independent loci can occur at gametic and zygotic levels known asgametic LD and zygotic LD, respectively. Gametic LD is well known for its roles in fine-scale mapping of quantitative trait
Jiang Qi, Wang Zhiquan, Moore Stephen S, Yang Rong-Cai   +3 more
doaj   +1 more source

Identification of Genetic Loci Associated with Quality Traits in Almond via Association Mapping. [PDF]

PLoS ONE, 2015
To design an appropriate association study, we need to understand population structure and the structure of linkage disequilibrium within and among populations as well as in different regions of the genome in an organism.
Carolina Font i Forcada, Nnadozie Oraguzie, Sebastian Reyes-Chin-Wo, Maria Teresa Espiau, Rafael Socias i Company, Angel Fernández i Martí   +5 more
doaj   +1 more source

Overall linkage disequilibrium. [PDF]

, 2012
Wn is displayed for each gene pair in a full-length KIR haplotype. Lighter shades indicate lower linkage disequilibrium and represent Wn approaching 0. Darker shades indicate higher linkage disequilibrium and represent Wn values approaching 1. Since they
David Roe (122513), Neng Yu (122546), Tao Wang (12008), Lihua Hou (122519), Harriet Noreen (122554), Martin Maiers (122566), Tatiana Lebedeva (122542), Elaine Reed (122538), Stephen Spellman (122563), Cynthia Vierra-Green (122507), Jill A. Hollenbach (122557), Mary Stewart (122551), Carolyn Katovich Hurley (122526), Raja Rajalingam (122533), Lisbeth A. Guethlein (122560)   +14 more
core   +1 more source

An Artificially Selected Cytokinin‐Pathway Transcription Factor Balances Soybean Yield and Pathogen Resistance

Advanced Science, EarlyView.
A cytokinin pathway transcription factor, RR2b, was artificially selected during soybean domestication and improvement based on its differential transcriptional activity, which correlates with ATT repeat polymorphisms in its promoter. RR2b balances yield and defense by fine‐tuning its expression level and offers a promising target for decoupling trade ...
Qun Ma, Yaqing Chen, Yiwen Gao, Xueting Hu, Qun Yang, Yucheng Liu, Peiyong Xin, Jijun Yan, Jinfang Chu, Lei Li, Zhixi Tian, Bo Ren   +11 more
wiley   +1 more source

Population genomics: Linkage disequilibrium holds the key [PDF]

, 2001
Current efforts to find disease-causing genes depend on patterns of linkage disequilibrium in human populations. Recent work has shown that linkage disequilibrium can extend over much larger genomic regions than expected, and that the patterns of linkage
Goldstein, David B., Weale, Michael E., Goldstein, D B, Weale, M E   +3 more
core   +1 more source

Transposable Element–Driven PIEZO Mutation Enhances Locust Flight in Plateau Hypoxia

Advanced Science, EarlyView.
Why transposable elements (TEs) persisted or expanded in genomes remains a mystery. Using integrated analysis of TE macro‐ and microevolution in locusts, our results showed that thousands of TE insertions promoted widespread adaptive variation. Subfamilies of candidate adaptive TEs amplified and reshaped species‐level genomic architecture.
Xuanzhao Li, Ying Liu, Longsheng Xing, Xianliang Huang, Yingming Sun, Lei Yue, Yuze Zhang, Huilong Du, Bing Chen   +8 more
wiley   +1 more source

Long-range linkage disequilibrium in French beef cattle breeds

Genetics Selection Evolution, 2021
Background Linkage disequilibrium (LD) is a key parameter to study the history of populations and to identify and fine map quantitative trait loci (QTL) and it has been studied for many years in animal populations.
Abdelmajid El Hou, Dominique Rocha, Eric Venot, Véronique Blanquet, Romain Philippe   +4 more
doaj   +1 more source