Results 121 to 130 of about 128,239 (292)

Variability of Leptin gene promoter in cattle

Italian Journal of Animal Science, 2010
A preliminary analysis on the variability of Leptin gene promoter in seven cattle breeds was carried out, focusing the attention on the SNP at nt 1759, which has been suggested to affect some quantitative traits in cattle.
L. Di Stasio, S. Sartore, C. Lisa
doaj   +1 more source

Integration of the arts and biomedical engineering in innovative interdisciplinary anatomy education: The synthetic anatomy module

Anatomical Sciences Education, EarlyView.
Abstract The intersection of science and art has historically fostered innovation, yet the integration of creative arts into anatomy education remains limited. The Synthetic Anatomy module was designed to bridge anatomy teaching with creative design for bioscience and biomedical engineering students. This study evaluates the module's educational impact
Mandeep Gill Sagoo, Pak Yin Lam, Leigh Wilson, Les Bicknell, Kawal Rhode, Siham Omar, Richard Wingate   +6 more
wiley   +1 more source

Cost‐effectiveness of DPYD genotyping prior to fluoropyrimidine‐based treatment for colorectal cancer in Wales

British Journal of Clinical Pharmacology, EarlyView.
Abstract Background Regulatory guidance in the United Kingdom advises DPYD genotyping prior to fluoropyrimidine‐based treatment. This economic evaluation estimated the costs and outcomes associated with DPYD screening prior to prescribing fluoropyrimidines for colorectal cancer in Wales and also considers additional variants to those included in ...
Catrin O. Plumpton, Sian M. Morgan, Richard A. Adams, Samantha Cox, Angharad A. Rudkin, Megan Fealey, Craig Barrington, Michelle D. Wood, Dyfrig A. Hughes   +8 more
wiley   +1 more source

UGT1A1 genotype testing for irinotecan: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, EarlyView.
Abstract Irinotecan, a topoisomerase I inhibitor, is available as both non‐pegylated and pegylated formulations. The non‐pegylated formulation is licensed for use in advanced colorectal cancer either in combination with other agents or as monotherapy.
Dharmisha Chauhan, Cinzia Dello Russo, Jack Thompson, Dyfrig A. Hughes, Katherine Payne, Maria Tsakiroglou, Paul Ross, Rena Chauhan, Simon Jenkinson, Jessica Keen, Sophie Harding, Eleanor Lau, Michael Braun, Roshan Agarwal, Richard Adams, Elisabeth Rolf, Farah Al‐Sheikhli, Sarah Mitchell, Ruth Hammond, Rosie Roberts, Lorna Cairns, Shirley Heggarty, Janet Graham, Justin Mencel, Munir Pirmohamed   +24 more
wiley   +1 more source

Pharmacogenomics of dolutegravir: A scoping review of evidence, gaps and clinical implications

British Journal of Clinical Pharmacology, EarlyView.
Dolutegravir underpins modern first‐ and second‐line HIV treatment regimens; however, interindividual variability in its disposition and tolerability presents challenges for optimal use. This scoping review mapped current evidence on the pharmacogenomics of dolutegravir, focusing on pharmacokinetics and pharmacodynamics, and methodological limitations ...
Ronald Kiguba, Mishael Ssesanga, Munir Pirmohamed   +2 more
wiley   +1 more source

A Genealogical Interpretation of Linkage Disequilibrium [PDF]

Genetics, 2002
Abstract The degree of association between alleles at different loci, or linkage disequilibrium, is widely used to infer details of evolutionary processes. Here I explore how associations between alleles relate to properties of the underlying genealogy of sequences.
openaire   +3 more sources

Linkage disequilibrium within DCDC2. [PDF]

, 2016
Linkage disequilibrium within DCDC2.
Yuping Zhang (136067), Jun Li (6494), Sandra M. Villafuerte (136072), Shuang Song (457799), Catherine McBride (2621557), Mengmeng Su (2621560), Twila Tardif (136069), Margit Burmeister (115305), Hua Shu (136087)   +8 more
core   +1 more source

Adaptive Genomic Divergence Across Altitudes in Capsella bursa‐pastoris

Biological Diversity, EarlyView.
Genomic divergence was observed between high‐altitude and low‐altitude populations of Capsella bursa‐pastoris in China, consistent with an important role of ecological factors. Candidate adaptive loci associated with enhanced energy metabolism, photoprotection, and growth plasticity under altitudinal stress were identified.
Lu Liu, Jia Li, Xin Liu, Xue‐Jun Ge, Hui‐Run Huang   +4 more
wiley   +1 more source

Assessment of Genetic Differentiation and Linkage Disequilibrium in Solanum pimpinellifolium Using Genome-Wide High-Density SNP Markers

G3: Genes, Genomes, Genetics, 2019
To mine new favorable alleles for tomato breeding, we investigated the feasibility of utilizing Solanum pimpinellifolium as a diverse panel of genome-wide association study through the restriction site-associated DNA sequencing technique.
Ya-Ping Lin, Chu-Yin Liu, Kai-Yi Chen
doaj   +1 more source

A robust linkage analysis method using combined allele sharing and transmission disequilibrium information from case-parent tetrad families [PDF]

, 2010
[[abstract]]There are two types of linkage information, the allele sharing information and transmission disequilibrium information, that can be extracted from case-parent tetrad families for deriving statistics for test of linkage.
Wang, JY (Wang, J. -Y.); Hou, CD (Hou, C. -D.); Tai, JJ (Tai, J. J.)
core   +1 more source