Results 141 to 150 of about 128,239 (292)

Causal correlations between inflammatory proteins and heart failure: A two‐sample Mendelian randomization analysis

ESC Heart Failure, Volume 12, Issue 2, Page 1374-1385, April 2025.
Abstract Aims Inflammation plays a critical role in both the development and progression of heart failure (HF), which is a leading cause of morbidity and mortality worldwide. However, the causality between specific inflammation‐related proteins and HF risk remains unclear.
Xian‐Guan Zhu, Gui‐Qin Liu, Ya‐Ping Peng, Li‐Ling Zhang, Xian‐Jin Wang, Liang‐Chuan Chen, Yuan‐Xi Zheng, Xue‐Jun Xiang, Rui Qiao, Xian‐He Lin   +9 more
wiley   +1 more source

A translational multimodal machine‐learning prototype predicting valproate response in epilepsy treatment

Epilepsia, EarlyView.
Abstract Objective Epilepsy affects ~1% of the global population and often requires lifelong antiseizure medication (ASM) therapy. Valproic acid (VPA) is a commonly prescribed first‐line ASM, yet only approximately half of patients achieve sustained seizure freedom. Treatment selection remains largely empirical.
Simeon Platte, Afsheen Kumar, Giorgia Guerini, Massimo Pandolfo, Denise Haslinger, Colin B. Josephson, Guillermo Delgado‐García, Navprabhjot Kaur, Michaela‐Pauline Lux, Heiko Stempfle, Chantal Depondt, Reetta Kälviäinen, Felix Rosenow, Sophie von Brauchitsch, Karl Martin Klein, Andreas G. Chiocchetti   +15 more
wiley   +1 more source

Linkage disequilibrium and genetic variability

Genetical Research, 1974
SUMMARYIt has been shown previously that, even in the absence of linkage, selection can cause an appreciable change in the genetic variance of a metric character due to disequilibrium; this change is temporary and is rapidly reversed when selection ceases.
openaire   +2 more sources

Multi‐Cohort Analysis Reveals Genetic Predispositions to Clonal Hematopoiesis as Mutation‐Specific Risk Factors for Stroke

Advanced Genetics, Volume 6, Issue 1, March 2025.
This study comprehensively evaluated the differential effect of clonal hematopoiesis (CH) mutations on the risk of various stroke subtypes and functional recovery. It shows that TET2 is associated with small vessel stroke possibly via a pro‐inflammatory pathway. Abstract Recent observational studies have found an association between Clonal Hematopoesis
Shuyang Lin, Yang E. Li, Yan Wang
wiley   +1 more source

Mesozoic–Cenozoic Thermochronology of the Tarim–Southern Tianshan System, NW China

Geological Journal, EarlyView.
Tectonothermal history of the Tarim–Southern Tianshan system compared with the major tectonic events at far‐field plate margins. ABSTRACT The Tarim Basin, an oil‐bearing basin in northwest China, is tectonically and sedimentologically linked to the Southern Tianshan Orogenic Belt.
Shuangfeng Zhao, Wen Chen, Jingbo Sun, Ze Shen, Jie Zhang   +4 more
wiley   +1 more source

Linkage and linkage disequilibrium analysis with high-throughput sequencing data [PDF]

, 2018
Genotyping with Uncertainty and Sequencing Data Two Packages: 1. Genotyping with Uncertainty and Sequencing data and linkage Mapping (GUSMap); Linakage analysis 2. Genotyping with Uncertainty and Sequencing data - Linkage Disequilibrium (GUS-LD); Linkage
Timothy Bilton (15394454)
core  

Geopolitics and global strategy: Making money under anarchy

Global Strategy Journal, EarlyView.
Abstract Research Summary Multinational firms conduct cross‐border trade and investment in a world of anarchy, where nation‐states must secure their survival in the absence of a world government. We develop a geopolitical‐economic order (GEO) framework to argue that the extent of geopolitical competition incentivizes states to create one of two types ...
Daniel J. Blake, Srividya Jandhyala, Quan Li   +2 more
wiley   +1 more source

Characterisation of linkage disequilibrium and subsequent estimation of effective population size in Thoroughbred horses using single nucleotide polymorphism markers [PDF]

, 2010
M Vaudin, JA Woolliams, Vaudin, M., LJ Corbin, Woolliams, J.A., SC Blott, Blott, S.C., Swinburne, J.E., Bishop, S.C., Corbin, L.J., SC Bishop, JE Swinburne   +11 more
core   +1 more source

The causal relationship between systemic lupus erythematosus and juvenile myoclonic epilepsy: A Mendelian randomization study and mediation analysis

Ibrain, Volume 11, Issue 1, Page 98-105, Spring 2025.
Mendelian randomization (MR) studies were conducted using the inverse‐variance weighted (IVW) method, MR‐Egger and weighted median on juvenile myoclonic epilepsy (JME), and systemic lupus erythematosus (SLE) data from the Integrative Epidemiology Unit (IEU) Open genome‐wide association study (GWAS) database and the International League Against Epilepsy
Sirui Chen, Ningning Zhang, Ruirui Zhang, Lan Zhang, Dadong Luo, Junqiang Li, Yaqing Liu, Yunan Wang, Xinyue Duan, Xin Tian, Tiancheng Wang   +10 more
wiley   +1 more source

LINKAGE DISEQUILIBRIUM WITH THE ISLAND MODEL

Genetics, 1982
ABSTRACT Linkage disequilibrium between two linked loci was studied for a finite population with a subdivided population structure. Wright's island model was used; extinction and replacement of colonies were also incorporated. Two alleles (A  1 and A  2 at the first locus, and B  1 and B  2 at the second locus) with symmetric mutation ...
openaire   +2 more sources