Linkage disequilibrium - Open Access .click

Results 141 to 150 of about 193,370 (286)

Combining the Underwater Vision Profiler 6 with sediment traps to measure in situ velocity of marine particles

Limnology and Oceanography: Methods, EarlyView.
Abstract Particles sinking from the surface to the deep ocean play a key role in the biological carbon pump, whose efficiency depends partly on sinking velocities. Over the last decade, in situ imaging has enabled critical advances in our understanding of particle dynamics in the ocean.
Manon Laget +5 more
wiley +1 more source

MendelR: A One‐Stop R Toolkit for Mendelian Randomization Analysis

Med Research, EarlyView.
ABSTRACT MendelR is a fully automated R package specifically developed for Mendelian randomization (MR) studies, designed to address the technical challenges of causal inference in biomedical research. As a powerful causal inference method, Mendelian randomization can effectively reduce confounding bias in observational studies.
Xiaohong Ke +4 more
wiley +1 more source

Linkage Disequilibrium [PDF]

, 2020
openaire +1 more source

Comprehensive Evidence for Mortality and Underlying Morbidity Related to Visceral Fat Distribution

Med Research, EarlyView.
ABSTRACT Linking obesity to mortality is an intriguing and controversial topic. This study tried to comprehensively assess 8 adiposity surrogates and mortality association among middle‐to‐old‐aged adults to identify a superior one, and explore explanatory disorders. Data sources included the National Health and Nutrition Examination Survey (NHANES), UK
Haolong Zhou +11 more
wiley +1 more source

Diabetic Peripheral Neuropathy: Molecular Staging, Risk Factors, Therapeutics, and Emerging Trends

Med Research, EarlyView.
The heterogeneous landscape of DPN can be unified through a tripartite pathogenic model encompassing progressive stages of metabolic dysregulation, chronic inflammation, and overt neuronal damage. Within this framework, six clinical subtypes were identified, namely, hyperglycemia‐driven, dyslipidemia‐driven, inflammation‐driven, dysvascularity‐driven ...
Xiaofeng Dai, Mingze Tang
wiley +1 more source

Genome‐Wide Assessment Reveals Ancestral Differences in Homozygosity Patterns Potentially Linked to Parkinson's Disease Etiology

Movement Disorders, EarlyView.
Abstract Background Recessive genetic variation and extended runs of homozygosity (ROHs) may contribute to the unexplained heritability of Parkinson's disease (PD), particularly in diverse and understudied populations. Objective We conducted the first large‐scale, multi‐ancestral investigation of PD to examine the impact of genome‐wide homozygosity on ...
Kathryn Step +680 more
wiley +1 more source

Efficient estimation for large-scale linkage disequilibrium patterns of the human genome. [PDF]

Elife, 2023
Huang X +5 more
europepmc +1 more source

Biomarkers of Leucine‐Rich Repeat Kinase 2 (LRRK2) and Lysosomal Dysfunction in Progressive Supranuclear Palsy

Movement Disorders, EarlyView.
Abstract Background Common and rare genetic variants in leucine‐rich repeat kinase 2 (LRRK2) have been linked with sporadic and familial Parkinson's disease (PD). Recently, we discovered that common genetic variation near the LRRK2 locus determined survival in progressive supranuclear palsy (PSP).
Louise‐Kristine Nielsen +27 more
wiley +1 more source

Correlation Between Gut Microbiota, Metabolites, and Diabetic Complications: A Two‐Sample Mendelian Randomization Study

Medicine Advances, EarlyView.
Fang et al. demonstrate a significant causal relationship among gut microbiota, gut metabolites, and diabetic complications, highlighting a biological link underlying mechanisms of diabetic vascular diseases. These findings provide important implications for future therapeutic strategy and risk prediction.
Jiaxi Fang +6 more
wiley +1 more source

Spatial Variability of Permafrost and Active Layer Thickness in a Forested Hillslope of the Taiga Shield

Permafrost and Periglacial Processes, EarlyView.
ABSTRACT Under continued climate warming, understanding present‐day permafrost distribution and the controls on ground thaw are critical for predicting permafrost thaw trajectories and associated implications. This study presents a high‐resolution investigation of permafrost extent and active layer thickness (ALT) across a coniferous forested hillslope
Alana Muenchrath, Christopher Spence, Andrew Ireson +2 more
wiley +1 more source

humans
genetics
medicine

models, genetic
gene frequency
alleles

genetic linkage
animals
chromosome mapping