Results 161 to 170 of about 128,239 (292)

Isolating transdiagnostic effects reveals specific genetic profiles in psychiatric disorders

JCPP Advances, EarlyView.
Abstract Background Evidence indicates substantial genetic overlap between psychiatric diagnoses. Accounting for these transdiagnostic effects can sharpen research on disorder‐specific genetic architecture and patterns of comorbidity. Methods We applied genomic structural equation modeling to genome‐wide association study summary statistics from 11 ...
Engin Keser, Wangjingyi Liao, Andrea G. Allegrini, Kaili Rimfeld, Thalia C. Eley, Robert Plomin, Margherita Malanchini   +6 more
wiley   +1 more source

Shared genetics between ADHD and reading/language abilities: Genome‐wide correlations, stratified enrichment, cross‐trait association, and mendelian randomization

JCPP Advances, EarlyView.
Abstract Background Attention‐deficit/hyperactivity disorder (ADHD) and language/reading difficulties frequently co‐occur. The extent of shared genetic architecture remains incompletely defined. We investigated genome‐wide overlap between ADHD and four core skills: word reading, nonword reading, spelling, and phoneme awareness.
Jinzhu Zhao, Shi Huang, Wei Liu, Feng Wang, Hong Qian, Xiaolin Hu   +5 more
wiley   +1 more source

Shared genetic and molecular architecture between neurodevelopmental disorders and type 1 diabetes

Journal of Intelligent Medicine, EarlyView.
Abstract Epidemiological and clinical studies have suggested possible associations between type 1 diabetes (T1D) and neurodevelopmental disorders (NDDs), but these relationships remain inconsistent across disorders and populations. To clarify whether such mixed findings, we investigated the genetic architecture linking T1D with autism spectrum disorder
Jingxuan Zhang, Zhentao Zhou, Lirong Zhu, Wei Liu   +3 more
wiley   +1 more source

Estimated Body Fat Percentage and Triglyceride‐Glucose Index for Identifying MASLD in Lean Asian Adults: A Cross‐Sectional Analysis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) is increasingly prevalent among lean Asian populations, yet effective strategies for identifying high‐risk individuals remain limited. We investigated the associations of body fat percentage (BF%) and the triglyceride‐glucose (TyG) index with lean MASLD and evaluated their ...
Xiang‐Ran Kong, Ya‐Li Chen, Rui Li, Lu‐Xiang Shang, Sha Sha   +4 more
wiley   +1 more source

PolyAdapt: Characterizing Polygenic Adaptive Architectures in the Presence of Strong Linkage Disequilibrium. [PDF]

Genome Biol Evol
Mazzucco R, Schlötterer C.
europepmc   +1 more source

Strategic Reconfiguration of Agriculture Sustainability in APEC Countries: Trade Exposure, Technological Transition, and Climate Constraints

Land Degradation &Development, EarlyView.
ABSTRACT In developing economies, the agricultural sector enhances national food security, employment, and economic prosperity, while it is also closely linked to the ecological system. International trade, technological innovations, and fertilizer use are modern inputs to increase output; however, their unsustainable use leads to environmental ...
Jie Yue, Yichen Yao, Bin Gong
wiley   +1 more source

X-LDR: an atlas of linkage disequilibrium across species. [PDF]

Genome Biol
Zhu TN, Huang X, Yang MY, Qi GA, Zhang QX, Lin F, Zhang W, Zhang Z, Jin X, Zheng HF, Xu HM, Yu S, Chen GB.   +12 more
europepmc   +1 more source

Unraveling the Spatiotemporal Dynamics and Nonlinear Drivers of Green Transition of Farmland Use in Major Grain‐Producing Areas: A Case Study of Jiangsu Province, China

Land Degradation &Development, EarlyView.
ABSTRACT Promoting the green transition of farmland use (GTFU) in major grain‐producing areas is essential for ensuring food security and advancing sustainable agricultural development. However, existing studies on GTFU have predominantly relied on static cross‐sectional analyses, with insufficient attention paid to its nonlinear driving mechanisms. To
Zhixian Sun, Yixuan Lu, Xinyue Zheng, Dongmei Zhang, Yian Xu, Guanxin Yao   +5 more
wiley   +1 more source

The effect of long-range linkage disequilibrium on allele-frequency dynamics under stabilizing selection. [PDF]

PLoS Genet
Negm S, Veller C.
europepmc   +1 more source

GWLD: an R package for genome-wide linkage disequilibrium analysis. [PDF]

G3 (Bethesda), 2023
Zhang R, Wu H, Li Y, Huang Z, Yin Z, Yang CX, Du ZQ.   +6 more
europepmc   +1 more source