Results 161 to 170 of about 401,091 (199)

Inferences about Linkage Disequilibrium

Biometrics, 1979
Existing theory for inferences about linkage disequilibrium is restricted to a measure defined on gametic frequencies. Unless gametic frequencies are directly observable, they are inferred from genotypic frequencies under the assumption of random union of gametes.
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Third order linkage disequilibrium*

Tissue Antigens, 1984
For third order linkage disequilibrium there is a constraint on the maximum value the disequilibrium can take, given pairwise disequilibria values and allele frequencies. As distinct from second order disequilibrium (considered in the context of a two locus model) there is also in some cases a constraint on the minimum value. The appropriate procedures
G, Thomson, M P, Baur
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Linkage disequilibrium at the SCA2 locus

Journal of Medical Genetics, 1999
Spinocerebellar ataxia type 2 (SCA2) is caused by the expansion of an unstable CAG repeat encoding a polyglutamine tract. Repeats with 32 to 200 CAGs are associated with the disease, whereas normal chromosomes contain 13 to 33 repeats. We tested 220 families of different geographical origins for the SCA2 mutation.
O, Didierjean, G, Cancel, G, Stevanin, A, Dürr, K, Bürk, A, Benomar, A, Lezin, S, Belal, M, Abada-Bendid, T, Klockgether, A, Brice   +10 more
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Linkage disequilibrium in finite populations

Theoretical and Applied Genetics, 1968
A theoretical investigation has been made of the influence of population size (N) and recombination fraction (c) on linkage disequilibrium (D) between a pair of loci. Two situations were studied: (i) where both loci had no effect on fitness and (ii) where they showed heterozygote superiority, but no epistacy.If the populations are initially in linkage ...
W G, Hill, A, Robertson
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Linkage disequilibrium in the human genome

Nature, 2001
With the availability of a dense genome-wide map of single nucleotide polymorphisms (SNPs), a central issue in human genetics is whether it is now possible to use linkage disequilibrium (LD) to map genes that cause disease. LD refers to correlations among neighbouring alleles, reflecting 'haplotypes' descended from single, ancestral chromosomes.
D E, Reich, M, Cargill, S, Bolk, J, Ireland, P C, Sabeti, D J, Richter, T, Lavery, R, Kouyoumjian, S F, Farhadian, R, Ward, E S, Lander   +10 more
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The effect of mutation on linkage disequilibrium

Annals of Human Genetics, 1992
SummaryThe standard formula for the approach to linkage equilibrium between two diallelic loci, initially at disequilibrium, is expressed in terms of their probability of recombination (Li, 1955). By a simple extension, we show how to incorporate the effects of mutation at one or both loci.
Carothers, A. D., Wright, A. F.
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Linkage Disequilibrium or Epistasis?

Tissue Antigens, 1975
M, Segall, F H, Bach
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Linkage Disequilibrium and Association Mapping

Annual Review of Genomics and Human Genetics, 2008
Linkage disequilibrium refers to the association between alleles at different loci. The standard definition applies to two alleles in the same gamete, and it can be regarded as the covariance of indicator variables for the states of those two alleles. The corresponding correlation coefficient ρ is the parameter that arises naturally in discussions of ...
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Linkage Disequilibrium Between Rare Mutations.

Genetics, 2022
Benjamin H. Good
exaly  

[Linkage disequilibrium].

Journal de genetique humaine, 1981
The linkage disequilibrium which measures the association between linked genes is a temporary phenomenon in a population because of crossing over. But such associations persist in HLA system. These persistent linkage disequilibria may be due to the very small fraction of recombinaison between the loci but other explanations are possible: selection or ...
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