Results 171 to 180 of about 193,370 (286)

Association of insomnia, insulin resistance traits, and cardiovascular disease risk: A two‐step Mendelian randomization study

Sleep Research, EarlyView.
The causal roles of metabolic traits in mediating the effects of insomnia on CVDs. CAD, coronary artery disease; HbA1c, hemoglobin A1c; HDL‐C, high‐density lipoprotein cholesterol; IR, insulin resistance; MI, myocardial infarction; TG, triglyceride; T2DM, type 2 diabetes.
Binhe Yu, Yanmin Xu, Xiaoyu Wang, Shuo Ye, Ruixiang Cui, Yujing Sun, Meng Li, Yan Li, Wenhui Yuan, Sheng Guo, Zhigang Chen, Xiaohong Kang, Sizhi Ai   +12 more
wiley   +1 more source

A gene-based model of fitness and its implications for genetic variation: linkage disequilibrium. [PDF]

Genetics
Johri P, Charlesworth B.
europepmc   +1 more source

Estimating linkage disequilibrium and selection from allele frequency trajectories. [PDF]

Genetics, 2023
Li Y, Barton JP.
europepmc   +1 more source

Identification of genetically predicted protein biomarkers and drug targets for prostate cancer via Mendelian randomization

VIEW, EarlyView.
Prostate cancer, a leading cause of cancer in men globally, urgently requires improved diagnostic and treatment strategies. This study analyzed large genetic datasets and identified five key proteins (THBD, DST, IFI27L2, OSBPL10, PPP1R14A) that either increase or decrease cancer risk, while also exploring their roles in immune response and potential ...
Maoping Cai, Tianming Peng, Zhiyue Xie, Chuqian Zhen, Chen Yao, Nan Peng, Qianyi Li, Yuzhong Yu, Jiming Bao, Xian‐Lu Song, Mingkun Chen, Shan‐Chao Zhao   +11 more
wiley   +1 more source

A reference panel for linkage disequilibrium and genotype imputation using whole-genome sequencing data from 2,680 participants across India. [PDF]

HGG Adv
Li Z, Zhao W, Zhou X, Leung YY, Schellenberg GD, Wang LS, Schönherr S, Forer L, Fuchsberger C, Dey S, Lee J, Smith JA, Dey AB, Kardia SLR.   +13 more
europepmc   +1 more source

Genetic diversity, linkage disequilibrium, and population structure of tetraploid wheat landraces originating from Europe and Asia. [PDF]

BMC Genomics, 2023
Rabieyan E, Darvishzadeh R, Mohammadi R, Gul A, Rasheed A, Akhar FK, Abdi H, Alipour H.   +7 more
europepmc   +1 more source

Integrative Analysis of Plasma Proteome and Genome Reveals Novel Drug Targets for Chronic Rhinosinusitis and Nasal Polyps

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) and nasal polyps (NP) are chronic inflammatory conditions with unsatisfactory treatment outcomes due to frequent recurrence of refractory disease. Identifying new therapeutic targets is essential. Methods We conducted a proteome‐wide Mendelian randomization (MR) analysis by integrating genome‐wide ...
En Zhou, Shi Luo, Yu Xiao, Bin Liu, Xu‐Ping Xiao   +4 more
wiley   +1 more source

Improving multibreed genomic prediction for breeds with small populations by modeling heterogeneous genetic (co)variance blockwise accounting for linkage disequilibrium. [PDF]

J Anim Sci Biotechnol
Li W, Li S, Du H, Huang Q, Zhuo Y, Zhou L, Cheng J, Li W, Jiang J, Liu J.   +9 more
europepmc   +1 more source

Linkage disequilibrium suggests genomic stability in Omicron clades of SARS-CoV-2 from the ASEAN countries. [PDF]

J Travel Med, 2023
Yusof NBM, Khor ZS, Bakar RSBA, Zaman KHBK, Chem YK, Fatini NA, Salleh NHB, Sengol S, Chin S, Prum S, Chhe V, Vy P, Mirasin A, Ibarahim NA, Azhar I, Momin MHFA, Hafneh NA, Ikawati HD, Pawestri HA, Nugraha AA, Puspa KD, Rojanawiwat A, Okada PA, Phuygun S, Thanadachakul T, Piromtong P, Phuong HVM, Trang UTH, Anh NP, Son NV, Thanh LT, Noordin NM, Tan JL.   +32 more
europepmc   +1 more source

Sex Hormones and the Risk of Nasal Polyps: A Two‐Sample Mendelian Randomization Study

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective The pathophysiological roles of sex hormones in airway inflammation have drawn much attention recently. We aimed to explore the causal effect of sex hormones on chronic rhinosinusitis (CRS) and nasal polyps (NP) via a Mendelian randomization (MR) study.
Ying Zhu, Jia‐Yao Zhou, Shi‐Yao Zhang, Ru Tang, Chun‐Yu Luo, Yue‐Long Gu, Zhi‐Peng Li, Wei‐Tian Zhang   +7 more
wiley   +1 more source