Results 161 to 170 of about 537,873 (344)

From multi‐omics to precision medicine in intracranial aneurysm: Biomarker discovery and multimodal integration

Interdisciplinary Medicine, EarlyView.
This review explores intracranial aneurysm biomarker discovery through multi‐omics. It reveals key genes, proteins, and metabolites, and shows how machine‐learning‐based multi‐modal integration may aid diagnosis and treatment. Abstract Despite extensive research, currently, no biomarkers are available for clinical use in intracranial aneurysm (IA ...
Jiaxin Zhang, Yufei Yang, Bingxu Chen, Yanmeng Zhao, Haitao Sun   +4 more
wiley   +1 more source

Accurate and efficient estimation of local heritability using summary statistics and the linkage disequilibrium matrix. [PDF]

Nat Commun, 2023
Li H, Mazumder R, Lin X.
europepmc   +1 more source

Linkage Disequilibrium between the Spinocerebellar Ataxia 3/Machado‐Joseph Disease Mutation and Two Intragenic Polymorphisms, One of Which, X359Y, Affects the Stop Codon [PDF]

, 1997
Giovanni Stévanin, Anne‐Sophie Lebre, Cecile Mathieux, Géraldine Cancel‐Tassin, Nacer Abbas, Olivier Didierjean, Alexandra Dürr, Yvon Trottier, Y. Agid, Alexis Brice   +9 more
openalex   +1 more source

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

bioRxiv, 2015
B. Vilhjálmsson, Jian Yang, H. Finucane, A. Gusev, S. Lindström, S. Ripke, G. Genovese, Po-Ru Loh, G. Bhatia, R. Do, Tristan J. Hayeck, H. Won, S. Kathiresan, M. Pato, C. Pato, R. Tamimi, E. Stahl, N. Zaitlen, B. Pasaniuc, M. Schierup, P. D. De Jager, N. Patsopoulos, S. Mccarroll, M. Daly, S. Purcell, D. Chasman, B. Neale, M. Goddard, P. Visscher, P. Kraft, N. Patterson, A. Price   +31 more
semanticscholar   +1 more source

Four Pharmacogenomic Variants Strongly Linked to Corticosteroid‐Induced Avascular Necrosis in Children with Cancer

The Journal of Clinical Pharmacology, EarlyView.
Abstract Corticosteroids are effective anti‐cancer agents for treating hematologic malignancies in children. However, avascular necrosis (AVN) is a common and debilitating adverse effect, leading to bone death and impacting long‐term quality of life. This study aimed to uncover the genetic factors contributing to corticosteroid‐induced AVN in a well ...
Miguel Cordova‐Delgado, Erika N. Scott, Shahrad R. Rassekh, Catrina M. Loucks, Wan‐Chun Chang, Edward J. Raack, Jessica N. Trueman, Colin J. D. Ross, Bruce C. Carleton, the Canadian Pharmacogenomics Network for Drug Safety Consortium   +9 more
wiley   +1 more source

LDmat: efficiently queryable compression of linkage disequilibrium matrices. [PDF]

Bioinformatics, 2023
Weiner RJ, Lakhani C, Knowles DA, Gürsoy G.   +3 more
europepmc   +1 more source

Attention Deficit Hyperactivity Disorder and other neurodevelopmental traits are associated with impact on functioning among children in the general population

JCPP Advances, EarlyView.
Abstract Background Attention Deficit Hyperactivity Disorder (ADHD) is commonly defined as a categorical diagnosis requiring clinically severe symptoms and impact on functioning. However, ADHD and other neurodevelopmental traits are also distributed continuously in the general population, where their impact on functioning is less clear.
Louise Horstmann, Charlotte A. Dennison, Evie Stergiakouli, Kate Langley, Joanna Martin   +4 more
wiley   +1 more source

Genetic diversity, linkage disequilibrium, and population structure of tetraploid wheat landraces originating from Europe and Asia. [PDF]

BMC Genomics, 2023
Rabieyan E, Darvishzadeh R, Mohammadi R, Gul A, Rasheed A, Akhar FK, Abdi H, Alipour H.   +7 more
europepmc   +1 more source

Linkage Disequilibrium at the ADH2 and ADH3 Loci and Risk of Alcoholism [PDF]

, 1999
Michael V. Osier, A.J. Pakstis, Judith R. Kidd, Jia-Fu Lee, Shih‐Jiun Yin, Huei‐Chen Ko, Howard J. Edenberg, Ru‐Band Lu, Kenneth K. Kídd   +8 more
openalex   +1 more source

Linkage disequilibrium–dependent architecture of human complex traits shows action of negative selection

Nature Genetics, 2017
S. Gazal, H. Finucane, N. Furlotte, Po-Ru Loh, P. Palamara, Xuanyao Liu, A. Schoech, B. Bulik-Sullivan, B. Neale, A. Gusev, A. Price   +10 more
semanticscholar   +1 more source