Results 81 to 90 of about 177,696 (251)

Gut microbiota and risk of heart failure in European population—A comprehensive Mendelian randomization study

ESC Heart Failure, EarlyView.
Abstract Aims Gut dysbiosis is proven to be involved in the pathogenesis and progression of heart failure (HF). Hindering the detrimental effects of gut‐heart axis is an emerging trend. Our goal is to investigate the causal relationship between gut microbiota and HF, with the aim of facilitating future exploration of microbiome‐targeted approaches to ...
Liyan Huang, Xuemei Zhao, Jing Wang, Jingyuan Guan, Boping Huang, Jiayu Feng, Xinqing Li, Yuhui Zhang, Jian Zhang   +8 more
wiley   +1 more source

Maintenance of genetic diversity in subdivided populations using genomic coancestry matrices

Molecular Ecology Resources, EarlyView., 2023
Abstract For both undivided and subdivided populations, the consensus method to maintain genetic diversity is the Optimal Contribution (OC) method. For subdivided populations, this method determines the optimal contribution of each candidate to each subpopulation to maximize global genetic diversity (which implicitly optimizes migration between ...
Elisabeth Morales‐González, Beatriz Villanueva, Miguel Á. Toro, Jesús Fernández   +3 more
wiley   +1 more source

Identification of TUB as a novel candidate gene influencing body weight in humans [PDF]

, 2006
Previously, we identified a locus on 11p influencing obesity in families with type 2 diabetes. Based on mouse studies, we selected TUB as a functional candidate gene and performed association studies to determine whether this controls obesity.
Custers, A., Dolle, M.E., Feskens, E.J., Hofker, M.H., Koeleman, B.P., Lindsey, P.J., Shiri-Sverdlov, R., van der A, A.D., van Gorp, P.J., van Haeften, T.W., van Tilburg, J.H., van Vliet-Ostaptchouk, J.V., Wijmenga, C., Zhernakova, S.   +13 more
core   +5 more sources

GEO combined with quantitative protein trait loci identify causative proteins in hypertrophic cardiomyopathy

ESC Heart Failure, EarlyView.
Abstract Aims Hypertrophic cardiomyopathy (HCM) is a rare genetic heart disease characterized by a limited patient population and scarce research and treatment resources. This study aimed to identify HCM‐associated proteins by integrating cardiac tissue data from the Gene Expression Omnibus (GEO) database with the latest protein quantitative trait ...
Bo Li, Xu Zhao, Yan Ding, Yi Zhang
wiley   +1 more source

The practice and promise of temporal genomics for measuring evolutionary responses to global change

Molecular Ecology Resources, EarlyView., 2023
Abstract Understanding the evolutionary consequences of anthropogenic change is imperative for estimating long‐term species resilience. While contemporary genomic data can provide us with important insights into recent demographic histories, investigating past change using present genomic data alone has limitations.
René D. Clark, Katrina A. Catalano, Kyra S. Fitz, Eric Garcia, Kyle E. Jaynes, Brendan N. Reid, Allyson Sawkins, Anthony A. Snead, John C. Whalen, Malin L. Pinsky   +9 more
wiley   +1 more source

THE SAMPLING DISTRIBUTION OF LINKAGE DISEQUILIBRIUM [PDF]

Genetics, 1984
ABSTRACT The probabilities of obtaining particular samples of gametes with two completely linked loci are derived. It is assumed that the population consists of N diploid, randomly mating individuals, that each of the two loci mutate according to the infinite allele model at a rate µ and that the population is at equilibrium. When 4Nµ is
openaire   +3 more sources

Heritability and causality of QRS duration and chronic heart failure risk

ESC Heart Failure, EarlyView.
Methodological framework used to investigate the heritability using linkage disequilibrium score regression (LDSC) and causal relationship between QRS duration (exposure) and chronic heart failure (outcome) using Mendelian randomization. QRS data were sourced from GWAS and exome‐wide association studies (EWAS), and chronic heart failure GWAS data were ...
Zequn Zheng, Xinhan Li, Yongfei Song
wiley   +1 more source

Management and conservation implications of cryptic population substructure for two commercially exploited fishes (Merluccius spp.) in southern Africa

Molecular Ecology Resources, EarlyView., 2023
Abstract Genomic information can aid in the establishment of sustainable management plans for commercially exploited marine fishes, aiding in the long‐term conservation of these resources. The southern African hakes (Merluccius capensis and M. paradoxus) are commercially valuable demersal fishes with similar distribution ranges but exhibiting ...
Sarah Forde, Sophie von der Heyden, Alan Le Moan, Erica S. Nielsen, Deon Durholtz, Paulus Kainge, Johannes N. Kathena, Marek R. Lipinski, Hilkka O. N. Ndjaula, Conrad A. Matthee, Romina Henriques   +10 more
wiley   +1 more source

Effect of linkage disequilibrium on inferences of population structure and introgression of iberian and black honey bees [PDF]

, 2012
Identification of population structure, a primary goal in population genetics, is easily performed because there is a number of methods available, implemented by user-friendly software packages.
Chávez-Galarza, Julio, De la Rúa, Pilar, Henriques, Dora, Johnston, J. Spencer, Kryger, Per, Pinto, M. Alice, Rufino, José   +6 more
core   +1 more source

Deciphering the Potential Causal and Prognostic Relationships Between Gut Microbiota and Brain Tumors: Insights from Genetics Analysis and Machine Learning

Exploration, EarlyView.
The causal relationship between gut microbiota and brain tumors and potential prognostic value of microbiota are still unclear. This study confirmed the causal effects of specific gut microbiota on three common brain tumors and identified microbe‐related genes that are expressed in brain tissue and correlated with the abundance of gut microbiota ...
Changwu Wu, Fushu Luo, Yongye Zhu, Chunbo Liu, Zheng Chen, Xiangyu Wang, Jun Tan, Qing Liu   +7 more
wiley   +1 more source