Results 81 to 90 of about 199,519 (335)

Stimuli‐Responsive Supramolecular Biomaterials for Cancer Theranostics

Advanced Science, EarlyView.
The ultimate goal of cancer theranostics is to get imaging agents and therapeutic cargo to tumor sites when and where they are required. “Smart” systems should be developed. This review discusses the characteristics of physiological stimuli, types and action modes of external stimuli, construction approaches and working principles, as well as ...
Wenting Hu, Binglin Ye, Guocan Yu, Feihe Huang, Zhengwei Mao   +4 more
wiley   +1 more source

Inferring linkage disequilibrium from non-random samples^†

BMC Genomics, 2010
Background Linkage disequilibrium (LD) plays a fundamental role in population genetics and in the current surge of studies to screen for subtle genetic variants affecting complex traits.
Hu Xiaohua, Wang Lin, Jiang Ning, Jia Tianye, Wang Minghui, Luo Zewei   +5 more
doaj   +1 more source

Testing Linkage Disequilibrium in Sibships [PDF]

The American Journal of Human Genetics, 2000
We describe the use of multivariate regression for testing allelic association in the presence of linkage, using marker genotype data from sibships. The test is valid, provided that the correct mean structure is modeled but does not require the correlation structure within families to be specified. The test can be implemented using standard statistical
Siegmund, Kimberly D., Langholz, Bryan, Kraft, Peter, Thomas, Duncan C.   +3 more
openaire   +2 more sources

Natural Negative Feedback Loops Confer Indica‐Japonica Differentiation for Grain Size Homeostasis in Rice

Advanced Science, EarlyView.
This study reveals the genetic and molecular mechanisms controlling grain size homeostasis through fine‐tuning OsGRX8 self‐expression by two natural negative feedback loops functioning in redox‐dependent or ‐independent manners and identifies two self‐regulatory haplotypes (SRHs) for the subspecies differentiation in rice.
Xingxing Li, Meng‐en Wu, Ziqi Qiao, Junkui Huang, Juncheng Zhang, Yang Ding, Junqing Zhu, Jingyue Xu, Yuxin Huang, Wei Li, Xiaomin Su, Yue Ding, Jianwei Zhang, Yibo Li   +13 more
wiley   +1 more source

Decay of linkage disequilibrium within genes across HGDP-CEPH human samples: most population isolates do not show increased LD

BMC Genomics, 2009
Background It is well known that the pattern of linkage disequilibrium varies between human populations, with remarkable geographical stratification.
Navarro Arcadi, Rosa Araceli, Gardner Michelle, Ferrer-Admetlla Anna, Moreno-Estrada Andrés, Casals Ferran, Morcillo-Suarez Carlos, Laayouni Hafid, Bosch Elena, Comas David, Graffelman Jan, Calafell Francesc, Bertranpetit Jaume   +12 more
doaj   +1 more source

Similar patterns of genetic diversity and linkage disequilibrium in Western chimpanzees (Pan troglodytes verus) and humans indicate highly conserved mechanisms of MHC molecular evolution

BMC Evolutionary Biology, 2020
Background Many species are threatened with extinction as their population sizes decrease with changing environments or face novel pathogenic threats.
Christelle Vangenot, José Manuel Nunes, Gaby M. Doxiadis, Estella S. Poloni, Ronald E. Bontrop, Natasja G. de Groot, Alicia Sanchez-Mazas   +6 more
doaj   +1 more source

Linkage Disequilibrium in Domestic Sheep [PDF]

Genetics, 2002
Abstract The last decade has seen a dramatic increase in the number of livestock QTL mapping studies. The next challenge awaiting livestock geneticists is to determine the actual genes responsible for variation of economically important traits.
McRae, AF, McEwan, JC, Dodds, KG, Wilson, T, Crawford, AM, Slate, J   +5 more
openaire   +2 more sources

Tobacco Smoke Exposure From Prenatal To Adolescent Periods Drives IBD Pathogenesis: Dynamic DNA Methylation Signatures Across Lifespan Stages

Advanced Science, EarlyView.
This study illustrates that maternal smoking during pregnancy (MSDP) is an independent risk factor for IBD in offspring, and DNA methylation serves as a key mechanistic pathway connecting early‐life smoking exposure with IBD risk in offspring. That highlights the urgent need for preventive interventions targeting prospective parents and minors to ...
Han Zhang, Jianhui Zhao, Jie Chen, Xinyi Ma, Siyun Zhou, Alexandra Noble, Rahul Kalla, Judith Wellens, Kun Liu, Evropi Theodoratou, Jack Satsangi, Xue Li   +11 more
wiley   +1 more source

Models and partition of variance for quantitative trait loci with epistasis and linkage disequilibrium

BMC Genetics, 2006
Background A genetic model about quantitative trait loci (QTL) provides a basis to interpret the genetic basis of quantitative traits in a study population, such as additive, dominance and epistatic effects of QTL and the partition of genetic variance ...
Wang Tao, Zeng Zhao-Bang
doaj   +1 more source

Long range linkage disequilibrium across the human genome. [PDF]

PLoS ONE, 2013
Long-range linkage disequilibria (LRLD) between sites that are widely separated on chromosomes may suggest that population admixture, epistatic selection, or other evolutionary forces are at work. We quantified patterns of LRLD on a chromosome-wide level
Evan Koch, Mickey Ristroph, Mark Kirkpatrick   +2 more
doaj   +1 more source