Results 61 to 70 of about 2,706,002 (277)
FEBS Letters, EarlyView.Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu +17 more
wiley +1 more source
, 2016 Linked Data opens up structured data from databases to be searched and queried via the web, and a geographic element is increasingly being used to link to those data. This book helps you understand how to organize and describe data that includes geographic content and how to publish it as Linked Data for the Semantic Web, as well as explaining the ...
Hart, Glen, Dolbear, Catherine
openaire +4 more sources
FEBS Letters, EarlyView.Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria +3 more
wiley +1 more source
IEEE Access, 2016 The design of solutions that are able to exploit the available data collected in smart cities environments can lead to insights that can guide the implementation of approaches that have the potential to significantly improve the quality of life within a ...
Eleni Fotopoulou +7 more
doaj +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
Die nachhaltige Bewahrung einer Forschungsdatenbank durch Linked Data. Laut welchem Vokabular?
Library Ideas, 2019 Linked Data bietet die Möglichkeit nicht nur normkonforme Datensätze zur Verfügung zu stellen sonder auch nachhaltig und langfristig Metadaten zu bewahren, wenn diese zu Linked Data Vokabularen verknüpft sind. Aber welches Vokabular soll man nutzen?
Francesco Gelati
doaj +1 more source
FEBS Letters, EarlyView.Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli +10 more
wiley +1 more source
Data for the study of sex‐linked inheritance in Drosophila [PDF]
, 1912 T. H. Morgan, Eleth Cattell
openalex +1 more source
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source