Results 71 to 80 of about 29,602,235 (249)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
LHD: optimising linked data query processing using parallelisation
, 2013 In the past few years as large volume of Linked Data is being publishing, processing distributed SPARQL queries over the Linked Data cloud is becoming increasingly challenging.
Tiropanis, Thanassis +2 more
core +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
RDFS & OWL Reasoning for Linked Data
, 2014 Book chapterLinked Data promises that a large portion of Web Data will be usable as one big interlinked RDF database against which structured queries can be answered.
Umbrich, Jurgen +2 more
core +1 more source
A Linked Data Browser with Recommendations
2018 IEEE 30th International Conference on Tools with Artificial Intelligence (ICTAI), 2018 It is becoming more common to publish data in a way that accords with the Linked Data principles. In an effort to improve the human exploitation of this data, we propose a Linked Data browser that is enhanced with recommendation functionality. Based on a user profile, also represented as Linked Data, we propose a technique that we call LDRec that ...
Frederico Araújo Durão +1 more
openaire +3 more sources
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Introduction to Linked Data [PDF]
, 2019 This chapter presents Linked Data, a new form of distributed data on the web which is especially suitable to be manipulated by machines and to share knowledge.
Casanovas, Pompeu +2 more
core +1 more source
Applying Linked Data to Media Fragments and Annotations
, 2011 The Web applications today have been enriched with various multimedia resources and annotations. However, there is still a lack of semantic interlinking between media fragments and annotations, which leads to the insufficient index of inside content of ...
Wald, Mike, Wills, Gary, Li, Yunjia
core +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source