Results 101 to 110 of about 2,636,548 (285)
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Scaling Linearizable Range Queries on Modern Multi-Cores
ComputersIn this paper we introduce Range Query Timestamp Counter (RQ-TSC), a general approach to provide scalable and linearizable range query operations for highly concurrent lock-based data structures.
Chen Zhang, Zhengming Yi, Xinghui Zhu
doaj +1 more source
International Journal of Engineering and Advanced Technology, 2019 Numerous cyberinformaticians would concur that, had it not been for sensor arranges, the strong unification of dissipate/accumulate I/O and neural systems may never have happened. Truth be told, couple of electrical architects would differ with the advancement of deletion coding, which epitomizes the organized standards of machine learning [1].
N. Priya, C. Anuradha, B. Sundarraj
openaire +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
6 Simple Ways to Improve Education in Maryland
Nonpartisan Education Review, 2017 On October 25, 2017, Jerome Dancis appeared before Maryland's Commission on Innovation and Excellence in Education, chaired by William Brit Kirwan. The linked pdf is his written testimony.
Jerome Dancis
doaj
Minimizing radiation dose in dynamic radiation environment using Conflict-Based Incremental Planner
Nuclear Engineering and TechnologySince it is important to reduce the overall radiation dose of workers employed in radiation-related facilities, a multi-path finding algorithm, named Conflict-Based Search for Minimum Dose, was developed for minimum dose.
Minjae Lee +7 more
doaj +1 more source
Redistribution and Reelection under Proportional Representation: The Postwar Italian Chamber of Deputies [PDF]
We study incumbency advantage and the electoral returns to pork and patronage over ten legislative periods from 1948 to 1992 for two political parties — the Christian Democrats (DC) and the Italian Socialist Party (PSI) — in Italy’s lower house of ...
Golden, Miriam, Picci, Lucio
core +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
International Journal of Recent Technology and Engineering, 2019 The refinement of e-commerce has visual-ized Internet QoS, and current scenario suggest that the exploration of local-area net-works will soon emerge. Given the present status of simultaneous approaches, scholars broadly want the affirmed unification of von Neumann machines and extreme programming.
openaire +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source