Results 51 to 60 of about 619,805 (296)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

IMPLEMENTATION OF THE SKIP LIST DATA STRUCTURE WITH IT'S UPDATE OPERATIONS

مجلة كلية التربية للبنات, 2019
A skip list data structure is really just a simulation of a binary search tree. Skip lists algorithm are simpler, faster and use less space. this data structure conceptually uses parallel sorted linked lists.
Maha shakir Ibrahim
doaj  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Open science and phenotyping in UK administrative health, education and social care data: the ECHILD phenotype code list repository

International Journal of Population Data Science
Administrative health data, such as the Hospital Episode Statistics (HES), can be used to identify groups of people with a particular target condition, a process known as phenotyping.
Matthew A Jay, Kate Lewis, Difei Shi, Rebecca Langella, Tony Stone, Sorcha Ní Chobhthaigh, Ania Zylbersztejn, Ruth Blackburn, Katie Harron   +8 more
doaj   +1 more source

New data on the southern Iberian serpentinophyte flora (Andalusia, Spain)

Mediterranean Botany, 2018
This work updates the existing list of obligate endemic serpentinophytes of the southern Iberian Peninsula. Serpentine ecosystems are developed on ultramafic outcrops which, although rare, have a worldwide distribution. The highly evolved and specialized
Andrés Vicente Pérez-Latorre, Noelia Hidalgo-Triana, Baltasar Cabezudo   +2 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

The halo effect of high-end models in the jewelry industry

Future Business Journal
High-end models form the brand’s core value, influence its basic models. This study examines the integrated pricing mechanism by which the halo effect from high-end models in the jewelry industry influences both the list, secondary market prices of basic
Keisuke Okahara, Shin’ya Nagasawa
doaj   +1 more source

Does admission to the rich list drive listed firms to improve corporate social responsibility ---- based on the perspective of media attention

International Review of Economics & Finance
We document a significant positive correlation between a publicly listed firm's actual controller being named to the prestigious Hurun Rich List (the Rich List) and an increased commitment to corporate social responsibility (CSR) by the firm.
Jialan Huang, Yan Zhao, Libin Zhao, Danmei Li   +3 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Single Linked List [PDF]

, 2016
Arsip Kuliah Online 2016 Single Linked List adalah Linked List yang memiliki satu pointer sambungan ...
Kuliah Online, Arsip
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