Results 61 to 70 of about 608,973 (255)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

A comprehensive of transforms, Gabor filter and k-means clustering for text detection in images and video

Applied Computing and Informatics, 2016
The present paper presents one of the efficient approaches toward multilingual text detection for video indexing. In this paper, we propose a method for detecting textlocated in varying and complex background in images/video.
V.N. Manjunath Aradhya, M.S. Pavithra
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Making using administrative data easier: How To Guides and the Phenotype Code List Repository for ECHILD

International Journal of Population Data Science
Objectives Even experienced researchers face difficulties in finding and using administrative data and producing analysis-ready datasets. Here we describe two resources developed to support users of the Education and Child Health Insights from Linked ...
Matthew Jay, Kate Lewis, Difei Shi, Rebecca Langella, Tony Stone, Sorcha Ní Chobhthaigh , Ania Zylbersztejn, Ruth Blackburn, Katie Harron   +8 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The Networked Data Lab: What linked data can tell us about the elective care waiting list in the UK

International Journal of Population Data Science
Existing research on NHS elective care backlogs in the UK predominantly focuses on aggregate waiting list figures. Until recently there has been little analysis that uses patient-level data to disaggregate the waiting list, or which uses linked data to ...
Tom Prendergast, Hannah Knight, Benjamin Barr, Jessica Butler, Jodie Chan, Konstantinos Daras, Josh Elvidge-Murgatroyd, Anna Palczewska, Frank Popham, Marcus Yarwood   +9 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The ADAPT-HEAT Study: A Multi-Method Approach to Develop Recommendations for Drug Safety During Hot Weather (The CALOR List)—Study Protocol

Methods and Protocols
Certain medications may adversely affect health during hot days and heatwaves by altering chronic conditions, comorbidities, fluid balance, or impairing heat adaptation.
Maxie Bunz, Pascal Nohl-Deryk, Heike van de Sand, Katharina van Baal, Svenja Arendt, Alina Herrmann, Ingo Meyer, Adriana Poppe, Olaf Krause, Johannes Heck, Beate Sigrid Müller   +10 more
doaj   +1 more source

Validation of Linked Lists

International Journal of Engineering and Advanced Technology, 2019
Numerous cyberinformaticians would concur that, had it not been for sensor arranges, the strong unification of dissipate/accumulate I/O and neural systems may never have happened. Truth be told, couple of electrical architects would differ with the advancement of deletion coding, which epitomizes the organized standards of machine learning [1].
N. Priya, C. Anuradha, B. Sundarraj
openaire   +1 more source