Results 151 to 160 of about 3,440,234 (310)

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu   +11 more
wiley   +1 more source

Open accessibility data interlinking

open access: yes
This paper presents the research of using Linked Open Data to enhance accessibility data for accessible travelling. Open accessibility data is the data related to the accessibility issues associated with geographical data, which could benefit people with
Ding, Chaohai, Wald, Mike, Wills, Gary
core  

CEDAR: The Dutch Historical Censuses as Linked Open Data [PDF]

open access: yes, 2015
In this document we describe the CEDAR dataset, a five-star Linked Open Data representation of the Dutch historical censuses, conducted in the Netherlands once every 10 years from 1795 to 1971. We produce a linked dataset from a digitized sample of 2,288
Ashkpour, A.   +3 more
core  

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Linked Open Data: An Introduction

open access: yes
Linked Open Data refers to datasets that are publicly available, can be linked to other datasets, and can be interpreted and used not only by humans but also by machines. This presentation outlines the main principles of Linked Open Data and its underlying framework, the Semantic Web.
openaire   +2 more sources

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

open access: yesMolecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

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