Results 41 to 50 of about 40,024,399 (236)
Open Data from Earth Observation: from Big Data to Linked Open Data, through INSPIRE
Je-LKS: Journal of E-Learning and Knowledge Society, 2014 The increasing availability of Earth Observation and geographic data implies great opportunities for those capable to efficiently address the problems arising from the management of this huge amount of data.
Massimo Zotti, Claudio La Mantia
doaj +1 more source
DESIGN, DEVELOPMENT AND MAINTENANCE METHODOLOGY OF DOMAIN SEMANTIC PORTALS OF SCIENTIFIC AND TECHNICAL INFORMATION [PDF]
Научно-технический вестник информационных технологий, механики и оптики, 2018 Subject of Research.The paper deals with the problem of development and support of educational processes through the creation of specialized semantic portals based on Linked Open Data.
M. A. Navrotskiy +3 more
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
A Research Agenda for Linked Closed Data
, 2011 While it is preferable that Linked Data is published without access or licence restrictions, there will always remain certain datasets which, perhaps due to financial considerations, cannot be published as Linked Open Data.
Gibbins, Nicholas +4 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Museum Linked Open Data: Ontologies, Datasets, Projects
Digital Presentation and Preservation of Cultural and Scientific Heritage, 2018 The Galleries, Libraries, Archives and Museums (GLAM) sector deals with complex and varied data. Integrating that data, especially across institutions, has always been a challenge.
Vladimir Alexiev
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source