Results 71 to 80 of about 1,768,814 (253)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Quality Metrics for Linked Open Data [PDF]
, 2015 The vision of the Linked Open Data LOD initiative is to provide a model for publishing data and meaningfully interlinking such dispersed but related data. Despite the importance of data quality for the successful growth of the LOD, only limited attention has been focused on quality of data prior to their publication on the LOD.
Behshid Behkamal +2 more
openaire +1 more source
Processing Linked Open Data Cubes [PDF]
, 2015 A significant part of open data provided by governments and international organizations concerns statistics such as demographics and economic indicators. The real value, however, of open statistical data will unveil from performing analytics on top of combined datasets from disparate sources.
Efthimios Tambouris +2 more
openaire +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Open Data as a Key Factor for Developing Expert Systems: A Perspective from Spain
International Journal of Interactive Multimedia and Artificial Intelligence, 2013 The open data movement is relatively new but very significant, and potentially powerful. The overall intention is to make local, regional and national data available in a form that allows for direct manipulation.
Juan Manuel Cueva Lovelle +3 more
doaj +1 more source
Cultural gems linked open data: Mapping culture and intangible heritage in European cities. [PDF]
Data Brief, 2023 Consoli S +4 more
europepmc +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Open Data—Linked Data—Linked Open Data—Linguistic Linked Open Data (LLOD): A General Introduction [PDF]
, 2020 Chiarcos, Christian +1 more
openaire +2 more sources
Data management plans as linked open data: exploiting ARGOS FAIR and machine actionable outputs in the OpenAIRE research graph. [PDF]
J Biomed Semantics, 2023 Papadopoulou E +5 more
europepmc +1 more source