Results 81 to 90 of about 4,098,264 (291)

A special case of long distance agreement in Marathi

open access: yesGlossa, 2020
This paper discusses an unexplored case of long distance agreement (LDA) in Marathi in which agreement takes place across an embedded subjunctive clause. In this construction, three distinct heads- an embedded verb, a matrix verb and what appears to be a
Renuka Ozarkar
doaj   +2 more sources

An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels [PDF]

open access: yes, 2015
Voltage-gated sodium channels are essential proteins in brain physiology, as they generate the sodium currents that initiate neuronal action potentials.
Beltran-Alvarez, Pedro   +1 more
core   +1 more source

Antibody-drug conjugates in cancer therapy: applications and future advances

open access: yesFrontiers in Immunology
Antibody-Drug Conjugates (ADCs) represent an emerging cancer therapeutic strategy and are becoming increasingly significant in the field of public health.
Rou Long   +13 more
doaj   +1 more source

Linker Modification Strategies To Control the Prostate-Specific Membrane Antigen (PSMA)-Targeting and Pharmacokinetic Properties of DOTA-Conjugated PSMA Inhibitors.

open access: yesJournal of Medicinal Chemistry, 2016
Since prostate-specific membrane antigen (PSMA) is up-regulated in nearly all stages of prostate cancer (PCa), PSMA can be considered as a viable diagnostic biomarker and treatment target in PCa.
M. Benešová   +7 more
semanticscholar   +1 more source

Disorder in DNA-Linked Gold Nanoparticle Assemblies

open access: yes, 2005
We report experimental observations on the effect of disorder on the phase behavior of DNA-linked nanoparticle assemblies. Variation in DNA linker lengths results in different melting temperatures of the DNA-linked nanoparticle assemblies. We observed an
Ching-Hwa Kiang   +3 more
core   +1 more source

Modifications at the C-Terminus To Improve Pyrrole−Imidazole Polyamide Activity in Cell Culture [PDF]

open access: yes, 2009
Pyrrole−imidazole (Py-Im) hairpin polyamides are a class of small molecule DNA minor groove binding compounds that have been shown to modulate endogenous gene expression in cell culture.
Dervan, Peter B., Jacobs, Claire S.
core   +2 more sources

Universal linker phosphoramidite

open access: yesArkivoc, 2008
Universal Linker phosphoramidite was synthesized and employed for conversion of conventional nucleoside bound solid phase into the universal support. The latter was successfully tested in preparation of the 20mer oligonucleotide.
Alex Azhayev, Andrey Yagodkin
openaire   +2 more sources

Cooperativity and Frustration in Protein-Mediated Parallel Actin Bundles

open access: yes, 2009
We examine the mechanism of bundling of cytoskeletal actin filaments by two representative bundling proteins, fascin and espin. Small-angle X-ray studies show that increased binding from linkers drives a systematic \textit{overtwist} of actin filaments ...
B. Alberts   +6 more
core   +1 more source

A SEQUENTIAL DUAL CLEAVAGE OF THE ARYLSULFAMATE LINKER TO PROVIDE BOTH SULFAMATE AND PHENOL DERIVATIVES [PDF]

open access: yesChemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2015
Tyramine sulfamate was linked to the trityl chloride resin and this polymeric support used to introduce two levels of molecular diversity by formation of peptide bonds. A dual cleavage strategy next generated in a sequential way (without resin split) two
Diane Fournier   +2 more
doaj  

Convenient methods for preparing π-conjugated linkers as building blocks for modular chemistry

open access: yesBeilstein Journal of Organic Chemistry, 2009
Simple, straightforward and optimized procedures for preparing extended π-conjugated linkers are described. Either unsubstituted or 4-donor substituted π-linkers bearing a styryl, biphenyl, phenylethenylphenyl, and phenylethynylphenyl π-conjugated ...
Jiří Kulhánek   +2 more
doaj   +1 more source

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