Results 161 to 170 of about 1,174,621 (314)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

The Future of Interventional Keratoconus Management: Perspectives on Integrating Epithelium-on Oxygen-Enriched Cross-Linking into Comprehensive Care Pathways. [PDF]

Ther Clin Risk Manag
Beckman KA, Syed ZA, Gromacki SJ.
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Conceptual Linking: Ontology-based Open Hypermedia

, 2001
This paper describes the attempts of the COHSE project to define and deploy a Conceptual Open Hypermedia Service. Consisting of • an ontological reasoning service which is used to represent a sophisticated conceptual model of document terms and their ...
Bechhofer, S.; id_orcid, Wendy Hall, Hall, Wendy, Carr, Leslie, Sean Bechhofer, Carole Goble, Hall, W., Leslie Carr, Goble, Carole, Carr, L., Bechhofer, Sean   +10 more
core  

Photocross-linking activity-based probes to capture the dynamics of ubiquitin RING E3 ligase interactions. [PDF]

Biochem J
Chandler SF, Tatham MH, Branigan E, Nakasone MA, Makukhin N, Ciulli A, Hay RT.   +6 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Adult learning linking theory and practice

, 2014
"Solidly grounded in theory and research, but concise and practice-oriented, Adult Learning: Linking Theory and Practice is perfect for graduate students and practitioners alike.
Bierema, Laura L. 1964-, Merriam, Sharan B.   +1 more
core  

Psychometric evaluation and linking of the PHQ-9, QIDS-C, and VQIDS-C in a real-world population with major depressive disorder

Neuropsychiatric Disease and Treatment
Emily OC Palmer,1 Sheryl Ker,2 Miguel E Rentería,3 Thomas Carmody,4 A John Rush5,6 1Holmusk Europe Ltd, London, UK; 2KKT Technologies, Pte. Ltd, Singapore; 3QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia; 4Peter O’Donnell Jr.
Palmer EOC, Ker S, Rentería ME, Carmody T, Rush AJ   +4 more
doaj  

<i>Astragaloside</i> IV in Combination with <i>Tanshinone</i> IIA Ameliorates Cardiac Fibrosis After Myocardial Infarction by Inhibiting CTR1/ATOX1/LOX Axis-Mediated Collagen Cross-Linking in Myofibroblasts. [PDF]

Drug Des Devel Ther
Wang H, Lu M, Li Y, Zhang L, Hao J, Hu Y, Zhang Z, Li Y, Li C.   +8 more
europepmc   +1 more source