Results 41 to 50 of about 114,804 (355)

Single‐Cell Computational Frameworks for Quantifying BET Bromodomain Inhibitor Resistance and Screening Re‐Sensitizer Drugs in Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
To combat BET inhibitor resistance in triple‐negative breast cancer, we developed two single‐cell computational frameworks. FR20 quantifies resistance by integrating ferroptosis‐related gene signatures, while D‐FR20 screens for potential re‐sensitizers.
Haizhou Liu   +6 more
wiley   +1 more source

Cleaved Amplified Polymorphic Sequences (CAPS) Markers for Characterization of the LuFAD3A Gene from Various Flax (Linum usitatissimum L.) Cultivars

open access: yesAgronomy, 2022
Depending on the variety, flax (Linum usitatissimum L.) provides an oil rich in omega-3 acids (especially 50% α-linolenic acid) with proven health properties, and is used as a raw industrial material.
Magdalena Walkowiak   +4 more
doaj   +1 more source

Hydrated lime matrix decreases ruminal biohydrogenation of flaxseed fatty acids [PDF]

open access: yes, 2013
Omega-3 fatty acids are essential nutrients for humans, but dietary intake of these nutrients by many Americans is inadequate due to low consumption of omega-3-rich foods such as fish, walnuts, and flaxseed.
Alvarado, C.A.   +7 more
core   +3 more sources

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

open access: yesAdvanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang   +7 more
wiley   +1 more source

Alpha-linolenic acid inhibits hepatocellular carcinoma cell growth through Farnesoid X receptor/β-catenin signaling pathway

open access: yesNutrition & Metabolism, 2022
Background Altered lipid profiles are frequently present in cancer, and it is necessary to elucidate the role of changed lipid profiles in hepatocellular carcinoma (HCC). We conducted this study to investigate the changed lipid profile in HCC tissues and
Shu Feng   +5 more
doaj   +1 more source

Alpha-Linolenic Acid [PDF]

open access: yesCirculation, 2005
Although the fish-derived, long-chain omega-3 fatty acids (n-3 FA) may be considered “gifts from the sea” for cardiovascular health, the role of the land (or plant) -based n-3 FA α-linolenic acid (ALA) has been less clear. ALA is the 18-carbon, 3-double bond (C18:3n-3) precursor to eicosapentaenoic acid (EPA; C20:5n-3) and docosahexaenoic acid (DHA ...
openaire   +1 more source

Hemp (Cannabis sativa L.) as a Resource for Green Cosmetics: Yield of Seeds and Fatty Acids Composition of 20 Varieties under the Growing Conditions of Organic Farming in Austria [PDF]

open access: yes, 2004
The interest in hemp (non-drug Cannabis sativa L.) for skin care and cosmetic use is due to the high content of oil, especially unsaturated fatty acids in seed with technological and therapeutic effects.
Kobert, J.   +4 more
core  

Dual‐Responsive Dynamic Covalent Bond‐Based Assembly of Lipid‐Nanozyme Systems via Multi‐Target Synergy and Efficient Target Enrichment for Ischemic Stroke Therapy

open access: yesAdvanced Science, EarlyView.
This system adopts a biomimetic phospholipid structure, covalently binding iNOS inhibitors, neuroprotective agent PCA and vitamin E derivatives through pH/ROS dual‐responsive bonds, and assembles them with Prussian blue nanozyme to form PBB@AHA. It can efficiently penetrate the blood‐brain barrier and simultaneously release multiple active components ...
Mengcheng Guo   +9 more
wiley   +1 more source

PhytoMilk: Effects of botanical composition and harvest system of legume/grass silage on fatty acid, α-tocopherol and β-carotene concentration in organic forage and milk [PDF]

open access: yes, 2010
Red clover and high proportion of forage in dairy cow diet increases the concentration of bioactive substances in milk, e.g. unsaturated fatty acids and antioxidants. In the present experiment twenty-four Swedish Red dairy cows were fed three silages in
Gustavsson, Anne-Maj   +3 more
core  

Enhancing microRNA167A expression in seed decreases the α-linolenic acid content and increases seed size in Camelina sativa. [PDF]

open access: yes, 2019
Despite well established roles of microRNAs in plant development, few aspects have been addressed to understand their effects in seeds especially on lipid metabolism.
Grabowski, Paul   +4 more
core   +1 more source

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